Pharmaspire


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Pages: 182-193

Date of Publication: 30-Nov--0001

Design, synthesis, and characterization of new thiazolidinedione derivatives as potent __ampersandsignalpha;-glucosidase inhibitors

Author: Sobhi Gaba, Gurpreet Singh, Vikramdeep Monga

Category: Pharmaceutics

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Abstract:

In an effort to find new antidiabetic agents, we carried out the design and synthesis of new thiazolidinedione derivatives and evaluated them as __ampersandsignalpha;-glucosidase inhibitors. All the synthesized derivatives were evaluated for __ampersandsignalpha;-glucosidase inhibitory activity. All the derivatives showed good inhibitory potential against __ampersandsignalpha;-glucosidase with IC50 values ranging between 35.74 ---PlusMinusSymbol--- 0.134 and 12.29 ---PlusMinusSymbol--- 1.86 __ampersandsignmu;g/mL. Among all the synthesized derivatives, 12d emerged to be the most potential inhibitor of __ampersandsignalpha;-glucosidase bearing IC50 value of 12.29 ---PlusMinusSymbol--- 1.86 __ampersandsignmu;g/mL. Owing to the results, it can be concluded that the lead identified in the present study can be further explored for the design of potent __ampersandsignalpha;-glucosidase inhibitors as antidiabetic agents.

Keywords: Thiazolidinedione, ?-glucosidase inhibitors, antidiabetic agents, synthesis, in vitro studies

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