Pharmaspire


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Pages: 168-176

Date of Publication: 02-Jun-2022

Natural and multifunctional colloidal carriers: A new prospective in drug delivery

Author: Anamika Palak, Kuldeep Singh Yadav, Vineet Kumar Rai

Category: Pharmaceutics

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Abstract:

Oleosomes are oil comprising, intracellular, microcarriers of herbal origin which is constituted of oleosin proteins embedded in a monolayer of phospholipid and an internal core containing triacylglycerol (TAGs) that imitate their noteworthy benefits. These oil carriers are gaining momentum and receiving ample consideration in the arena of formulation development owing to their simple yet robust structure and their amenability to the biological system. They could be exploited to the development of proficient and explicit dosage forms with fewer ingredients and to deliver the specific drugs to the ultimate target. Their oleosin proteins are amphiphilic in nature and get self-emulsified even at very low temperature and hence lead to fewer ingredient such as emulsifiers and co-emulsifier into the system. Consequently, it offers emoliency, occlusivity, film forming action to the skin. They have ability to, load ingredients and to sustain/control their release for longer duration and hence may helpful to deliver drug, vitamin, fragrance, and many more through topical route. A review of patents revealed their massive applications in the development of variety of cosmetics, food products, personal care products, pharmaceutical products, industrial products, etc. Therefore, employing oleosomes in various formulation development procedures could be an applicable and cost-effective alternative to the synthetic ingredient based and controlled release formulations. The present review provides information about the nature and basic characteristics of oleosomes and focuses mainly on the key aspects of development of an effective formulation of natural origin.

Keywords: Drug delivery, drug loading, natural carriers, oleosomes, products

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