<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>isfcppharmaspire</PublisherName> <JournalTitle>Pharmaspire</JournalTitle> <PISSN>C</PISSN> <EISSN>o</EISSN> <Volume-Issue>Volume 16, Issue 01,2024</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>Jan-March</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>2024</Year> <Month>03</Month> <Day>7</Day> </PubDate> <ArticleType>Pharmacology</ArticleType> <ArticleTitle>Cost variation analysis of herbal phytoconstituents and nutraceuticals as a neuroprotective in neurodegenerative disorders</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>36</FirstPage> <LastPage>44</LastPage> <AuthorList> <Author> <FirstName>Shashikesh</FirstName> <LastName>Shukla</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Ashutosh</FirstName> <LastName>Ranjan</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Shamsher</FirstName> <LastName>Singh</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI>10.56933/Pharmaspire.2024.16104</DOI> <Abstract>Objective: The objective of the study was to find out the cost variation among herbal phytoconstituents and nutraceuticals used for the treatment of neurodegenerative disorders. Background: This paper discusses the cost-variation analysis of herbal phytoconstituents and nutraceuticals used as neuroprotective in neurodegenerative disorders. Neurodegenerative disorders are characterized by the loss of nerve cells in the various regions of the brain, which leads to problems such as cognitive impairments and motor problems. Herbal phytoconstituents and nutraceuticals are frequently used for neurodegenerative disorders. The turnover of the Indian herbal industry is more than Rs 80 billion. There are various pharmaceutical companies with innumerable brands, and there is great variability in the price of herbal phytoconstituents and nutraceutical formulations depending on the brand. Materials and Methods: The cost variation of various herbal phytoconstituents and nutraceuticals used in neurodegenerative disorders produced by different pharmaceutical companies in India was analyzed. The data was collected by authors from https://amazon. in, https://www.1mg.com, https://kiwla.com, https://netmeds.com, and https://thekiwla.com. Results: In India, 15 herbal phytoconstituents and nutraceuticals with 45 formulations under 390 brands produced by various pharmaceutical companies are used as neuroprotective. Among all the herbal phytoconstituents and nutraceuticals, the maximum percentage cost variation and cost ratio were found for Brahmi 500 mg. The minimum percentage cost variation and cost ratio were found for panax ginseng 1000 mg. Conclusion: We can conclude that there is a very high-cost variation in the different marketed formulations of herbal phytoconstituents and nutraceuticals used as neuroprotective in neurodegenerative disorders.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Amyotrophic lateral sclerosis, Herbal phytoconstituent, Neurodegenerative disorder, Nutraceutical</Keywords> <URLs> <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=15628&title=Cost variation analysis of herbal phytoconstituents and nutraceuticals as a neuroprotective in neurodegenerative disorders</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>1. Chi H, Chang HY, Sang TK. Neuronal cell death mechanisms in major neurodegenerative diseases. Int J Mol Sci 2018;19:3082. 2. Dugger BN, Dickson DW. 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