<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>isfcppharmaspire</PublisherName> <JournalTitle>Pharmaspire</JournalTitle> <PISSN>C</PISSN> <EISSN>o</EISSN> <Volume-Issue>Volume 16, Issue 01,2024</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>Jan-March</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>2024</Year> <Month>03</Month> <Day>7</Day> </PubDate> <ArticleType>Pharmaceutics</ArticleType> <ArticleTitle>Formulation and evaluation of herbal toothpaste</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1</FirstPage> <LastPage>12</LastPage> <AuthorList> <Author> <FirstName>Vaishali</FirstName> <LastName>Chugh</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Shivani</FirstName> <LastName>Dhiman</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Vishnu</FirstName> <LastName>Mittal</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Abhinav</FirstName> <LastName>Singhal</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI>10.56933/Pharmaspire.2024.16101</DOI> <Abstract>Introduction: Oral hygiene has become increasingly important globally in recent years. In conjunction with utilizing a toothbrush, toothpaste serves to keep the esthetics and dental health. Scope: This study examined the global significance of oral hygiene, emphasizing the integral role toothpaste plays in upholding both the esthetic appeal and health of teeth. This investigation extends beyond the conventional focus on plaque and debris removal, considering additional facets, such as combating bad breath and preventing tooth decay and gum disease through active ingredients. Objective: The purpose of this investigation was to compare the effects of herbal products on gum health and tooth enamel roughness with those of conventionally formulated toothpaste. The primary objective goal this research was to evaluate the effects of herbal toothpaste on both gum health and the surface roughness of tooth enamel. Herbal toothpastes have garnered public and professional approval due to their positive effects on teeth. Materials and Methods: This study employed a comparative approach, juxtaposing the effects of herbal and conventional toothpastes on gum health and tooth enamel roughness. Rigorous experimentation and analysis were conducted to measure and quantify these effects. Results: The findings of this study will shed light on the relative effects of herbal and conventional toothpastes on gum health and tooth enamel roughness. Across quantitative data and statistical analyses, this study attempts to offer a thorough grasp of the possible advantages and disadvantages connected with herbal oral care products compared to their traditional counterparts. Conclusion: The study came to the conclusion that herbal toothpaste is safer and has less negative effects than synthetic toothpaste, making it more noteworthy and accepted in dentistry research. The toothpaste’s formulation has anti-microbial action against pathogens and is effective in maintaining dental and oral hygiene. The preparation of the market in relation to the formulation.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Antimicrobial, Cure, Dentrifice, Diseases, Harsh chemicals, Herbs</Keywords> <URLs> <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=15625&title=Formulation and evaluation of herbal toothpaste</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>1. Kumar G, Jalaluddin MD, Rout P, Mohanty R, Dileep CL. Emerging trends of herbal care in dentistry. J Clin Diagn Res 2013;7:1827. 2. Abu-Rabia A. Urinary diseases and ethnobotany among pastoral nomads in the Middle East. J Ethnobiol Ethnomed 2005;1:4. 3. Lev E. Ethno-diversity within current ethnopharmacology as part of Israeli traditional medicine--a review. J Ethnobiol Ethnomed 2006;2:4. 4. Gazzaneo LR, de Lucena RF, de Albuquerque UP. Knowledge and use of medicinal plants by local specialists in an region of Atlantic forest in the state of Pernambuco (Northeastern Brazil). J Ethnobiol Ethnomed 2005;1:9. 5. Al-Qura’n S. Ethnobotanical survey of folk toxic plants in Southern part of Jordan. Toxicon 2005;46:119-29. 6. Hanazaki N, Tamashiro JY, Leitand;atilde;o-Filho H, Gegossi A. Diversity of plant uses in two Caiand;ccedil;ara communities from the Atlantic forest coast, Brazil. Biodivers Conserv 2000;9:597-615. 7. Rossato SC, De Leitand;atilde;O-Filho HF, Begossi A. Ethnobotany of Caicaras of the Atlantic forest coast (Brazil). Econ Bot 1999;53:387-95. 8. Azaizeh H, Fulder S, Khalil K, Said O. Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern Region. Fitoterapia 2000;74:98-108. 9. Principe P. Monetising the Pharmacological Benefits of Plants. Vol. 1. Washington, DC: United States Environmental Protection Agency; 1991. 10. George D, Bhat SS, Antony B. Comparative evaluation of the antimicrobial efficacy of Aloe vera tooth gel and two popular commercial toothpastes: An in vitro study. Gen Dent 2009;57:238-41. 11. Almas K. The antimicrobial effects of seven different types of Asian chewing sticks. Odontostomatol Trop 2001;24:17-20. 12. Sahu B, Mohanty R. Herbal toothpaste: A comprehensive overview. Indian J Public Health 2019;10:1283. 13. Kumar S, Patel S, Tadakamadla J, Tibdewal H, Duraiswamy P, Kulkarni S. Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. Int J Dent Hyg 2013;11:35-40. 14. Foulkes DM. Some toxicological observations on chlorhexidine. J Periodontal Res Suppl 1973;12:55-60. 15. Jeon JG, Rosalen PL, Falsetta ML, Koo H. Natural products in caries research: Current (limited) knowledge, challenges and future perspective. Caries Res 2011;45:243-63. 16. Kalesinskas P, Ka?ergius T, Ambrozaitis A, Pe?iulien? V, Ericson D. Reducing dental plaque formation and caries development. A review of current methods and implications for novel pharmaceuticals. Stomatologija 2014;16:44-52. 17. ?ener B, Kiliand;ccedil; M. Herbal extracts used in dental disorders. Biomed J Sci Tech Res 2019;19:14107-11. 18. Deshmukh P, Telrandhe R, Gunde M. Formulation and evaluation of herbal toothpaste: Compared with marketed preparation. Int J Pharm Drug Anal 2017;5:406-10. 19. Mani A, Thawani V. Are all additives of toothpastes rational? J Mahatma Gandhi Inst Med Sci 2019;24:71-4. 20. Bogdanich W. The Everyman who Exposed Tainted Toothpaste. Vol. 1. New York Times; 2007. 21. Khan FN, Thawani V. Can toothpaste carry drugs to fight pulmonary infections? J Mahatma Gandhi Inst Med Sci 2018;23:59-60. 22. Rule KL, Ebbett VR, Vikesland PJ. Formation of chloroform and chlorinated organics by free-chlorinemediated oxidation of triclosan. Environ Sci Technol 2005;39:3176-85. 23. Sibanda L, Niven V, Gallagher JE. Oral health and community nursing: A practical guide to the delivering better oral health toolkit for adults. Br J Community Nurs 2023;28:398-403. 24. Kidd EA, Fejerskov O. Essentials of Dental Caries. Oxford: Oxford University Press; 2016. 25. Lee HR, Hwang KA, Nam KH, Kim HC, Choi KC. Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol, via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models. Chem Res Toxicol 2014;27:834-42. 26. James P, Worthington HV, Parnell C, Harding M, Lamont T, Cheung A, Whelton H, Riley P. Chlorhexidine mouthrinse as an adjunctive treatment for gingival health. Cochrane Database Syst Rev 2017;3:CD008676. 27. Ahrari F, Hasanzadeh N, Rajabi O, Forouzannejad Z. Effectiveness of sodium bicarbonate combined with hydrogen peroxide and CPP-ACPF in whitening and microhardness of enamel. J Clin Exp Dent 2017;9:e344-350. 28. Riley P, Moore D, Ahmed F, Sharif MO, Worthington HV. Xylitol-containing products for preventing dental caries in children and adults. Cochrane Database Syst Rev 2015;2015:CD010743. 29. Fruijtier-Pand;ouml;lloth C. Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. Toxicology 2005;214:1-38. 30. Wenande E, Garvey LH. Immediate?type hypersensitivity to polyethylene glycols: A review. Clin Exp Allergy 2016;46:907-22. 31. American Dental Association. Description of Toothpaste. United States: American Dental Association; 2010. 32. Rathi NM. Formulation and evaluation study on herbal toothpaste: A review. Int J Novel Res Dev 2022;7:968-74. 33. Nishad U, Ali M, Maurya A. Formulation and evaluation of a polyherbal toothpaste using medicinal plants. J Pharm Sci Res 2020;12:105-11. 34. Adeleye OA, Bamiro O, Akpotu M, Adebowale M, Daodu J, Sodeinde MA. Physicochemical evaluation and antibacterial activity of Massularia acuminata herbal toothpaste. Turk J Pharm Sci 2021;18:476-82. 35. Divya S, Suresh J, Meenakshi S. Comprehensive review on herbal toothpaste. Ann Rom Soc Cell Biol. 2021;25:9509-18. 36. Shukla KV, Kumari D. Formulation development and evaluation of herbal toothpaste for treatment of oral disease. Drug Deliv Ther 2019;9:98-104. 37. Sadeghi-Nejad B, Moghimipour E, Yusef Naanaie SY, Nezarat S. Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro. Curr Med Mycol 2018;4:21-6. 38. Kokate CK, Purohit AP, Gokhale SB. In: Prakashan N, editor. Pharmacognosy. 31st ed. Pune: Nirali Prakashan; 2005. 39. Gautam D, Palkar P, Maule K, Singh S, Sawant G, Kuvalekar C, et al. Preparation, evaluation and comparison of herbal toothpaste with marketed herbal toothpaste. Asian J Pharm Technol 2020;10:165. 40. Oluwasina OO, Ezenwosu IV, Ogidi CO, Oyetayo VO. Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms. AMB Express 2019;9:20. 41. Mangilal T, Ravikumar M. Preparation and evaluation of herbal toothpaste and compared with commercial herbal toothpastes: An in vitro study. Int J Ayurvedic Herb Med 2016;6:2251-66. 42. Ur-Rehman S, Mushtaq Z, Zahoor T, Jamil A, Murtaza MA. Xylitol: A review on bioproduction, application, health benefits, and related safety issues. Crit Rev Food Sci Nutr 2015;55:1514-28. 43. Kankariya AR, Patel AR, Kunte SS. The effect of different concentrations of water soluble azadirachtin (neem metabolite) on Streptococcus mutans compared with chlorhexidine. J Indian Soc Pedod Prev Dent 2016;34:105-10. 44. Khan T, Tatke P, Gabhe SY. Immunological studies on the aerial roots of the Indian Banyan. Indian J Pharm Sci 2008;70:287-91. 45. Tian M, Yan H, Row KH. Extraction of glycyrrhizic acid and glabridin from licorice. Int J Mol Sci 2008;9:571-7. 46. Chowdhury BR, Garai A, Deb M, Bhattacharya S. Herbal toothpaste: A possible remedy for oral cancer. J Nat Prod 2013;2:44-55. 47. Abu RA. Urinary diseases and ethnobotany among pastoral nomads in the Middle East. J Ethnobiol Ethnomed 2005;1:4. 48. Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet 2007;369:51-9.</References> </References> </Journal> </Article> </ArticleSet>