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    <Journal>
      <PublisherName>isfcppharmaspire</PublisherName>
      <JournalTitle>Pharmaspire</JournalTitle>
      <PISSN>C</PISSN>
      <EISSN>o</EISSN>
      <Volume-Issue/>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season/>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Pharmacology</ArticleType>
      <ArticleTitle>Apigenin: A Promising Neuroprotective Agent for Neurodegenerative Diseases: Mechanisms, Preclinical Studies, and Therapeutic Potential</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>0</FirstPage>
      <LastPage>0</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Shamsher</FirstName>
          <LastName>Singh</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
        </Author>
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      <DOI/>
      <Abstract>Neurodegenerative diseases pose significant challenges to global healthcare systems, highlighting the urgent need for effective therapeutic strategies. Apigenin, a natural compound derived from various plant sources, has emerged as a potential treatment option due to its Neuroprotective properties. This review article provides a comprehensive overview of Apigenin, focusing on its definition, natural sources, pharmacokinetics, bioavailability, mechanisms of action, Safety, and tolerability profile. Apigenin exerts its neuroprotective effects through multiple mechanisms, including its antioxidant activity, anti-inflammatory properties, modulation of cellular signaling pathways, inhibition of protein misfolding and aggregation, and enhancement of mitochondrial function. In vitro, studies have demonstrated that Apigenin attenuates oxidative stress, inhibits the formation of protein aggregates, and suppresses neuroinflammation. Animal models, such as transgenic mice, rat models, and non-human primates, have provided valuable insights into the potential therapeutic benefits of Apigenin, including improved cognitive function, mitigation of motor impairments, and preservation of neuronal integrity. Apigenin's safety and tolerability profile appears favorable based on preclinical and clinical studies, with minimal reported adverse effects. However, further investigation is required to determine optimal dosing regimens and assess potential drug interactions. Additionally, while current treatment options for neurodegenerative diseases primarily focus on symptom management, Apigenin holds promise as a disease-modifying agent</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Apigenin,Neurodegenerative diseases,neuroprotection,pre-clinical studies,animal models</Keywords>
      <URLs>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=15099&amp;title=Apigenin: A Promising Neuroprotective Agent for Neurodegenerative Diseases: Mechanisms, Preclinical Studies, and Therapeutic Potential</Abstract>
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      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References/>
      </References>
    </Journal>
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