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  <Article>
    <Journal>
      <PublisherName>isfcppharmaspire</PublisherName>
      <JournalTitle>Pharmaspire</JournalTitle>
      <PISSN>C</PISSN>
      <EISSN>o</EISSN>
      <Volume-Issue>Volume 15, Issue 04, 2023</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>October-December</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2024</Year>
        <Month>02</Month>
        <Day>17</Day>
      </PubDate>
      <ArticleType>Pharmacy Practice</ArticleType>
      <ArticleTitle>Modern advances in epilepsy imaging used on the basis of cost: A review</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>278</FirstPage>
      <LastPage>282</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Hardik</FirstName>
          <LastName>Kumar</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Kamaljeet</FirstName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Shilpa</FirstName>
          <LastName>Debnath</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Amit</FirstName>
          <LastName>Sharma</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI>10.56933/Pharmaspire.2023.15142</DOI>
      <Abstract>Epilepsy is a chronic neurologic condition that affects social behavior, health, the economy, and social functioning. Worldwide, an estimated 5 million people are diagnosed with epilepsy each year. More than 50 million people are reportedly affected globally. 49% of epilepsy patients live in low-to middle-income countries; in exceptional situations, this number may reach 139/100,000 people. This review provides imaging therapy used for the diagnoses which are compared according to the cost of individual imaging techniques reliable or affordable for the patient. The main tools used to evaluate patients with epilepsy are electroencephalography (EEG), and the functional imaging modalities for epilepsy are positional emission tomography, single-photon emission computed tomography (CT), tissue ablation using high-intensity focused ultrasound, deep non-invasive neuromodulation, and blood–brain barrier opening using superficial targets, focused ultrasound, magnetoencephalography (MEG), and magnetic resonance imaging (MRI). In the differential diagnosis imaging findings, the treatment of epilepsy is significantly better. By comparing the one-time cost of all imaging techniques, the three techniques mostly used are CT, MRI, and EEG. Patients may easily access and afford these imagining techniques because they are readily available at low cost which lies between 1000 and 10,000 rupees.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Blood–brain barrier, Epilepsy, Focused ultrasound, Imaging techniques, Seizure</Keywords>
      <URLs>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=15075&amp;title=Modern advances in epilepsy imaging used on the basis of cost: A review</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>1. Radhakrishnan K. Challenges in the management of epilepsy in resource-poor countries. Nat Rev Neurol 2009;5:323-30.&#13;
2. World Health Organization. Epilepsy 2022; 2022. Available from: https://www.who.int/news-room/ fact-sheets/detail/epilepsy&#13;
3. Kumar H, Debnath S, Sharma A. Can epilepsy be cured? A review. Health Sci Rev 2022;5:100062. &#13;
4. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia 2014;55:475-82.&#13;
5. Bompori E, Niakas D, Nakou I, Siamopoulou-Mavridou A, Tzoufi MS. Comparative study of the health-related quality of life of children with epilepsy and their parents. Epilepsy Behav 2014;41:11-7.&#13;
6. Brodie MJ, Elder AT, Kwan P. Epilepsy in later life. Lancet Neurol 2009;8:1019-30.&#13;
7. Pellock JM. Understanding co-morbidities affecting children with epilepsy. Neurology 2004;62:S17-23.&#13;
8. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2197-223.&#13;
9. Sepanlou SG, Parsaeian M, Krohn KJ, Afshin A, Farzadfar F, Roshandel G, et al. Disability-adjusted lifeyears (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE) in Iran and its Neighboring countries, 1990-2015: Findings from global burden of disease study 2015. Arch Iran Med 2017;20:403-18.&#13;
10. Sidhu MK, Duncan JS, Sander JW. Neuroimaging in epilepsy. Curr Opin Neurol 2018;31:371-8.&#13;
11. Wiest R, Beisteiner R. Recent developments in imaging of epilepsy. Curr Opin Neurol 2019;32:530-8.&#13;
12. Chen KT, Wei KC, Liu HL. Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment. Front Pharmacol 2019;10:86.&#13;
13. Song KH, Harvey BK, Borden MA. State-of-the-art of microbubble-assisted blood-brain barrier disruption. Theranostics 2018;8:4393-408.&#13;
14. Downs ME, Teichert T, Buch A, Karakatsani ME, Sierra C, Chen S, et al. Toward a cognitive neural prosthesis using focused ultrasound. Front Neurosci 2017;11:607.&#13;
15. Todd N, Zhang Y, Arcaro M, Becerra L, Borsook D, Livingstone M, et al. Focused ultrasound induced opening of the blood-brain barrier disrupts inter-hemispheric resting state functional connectivity in the rat brain. Neuroimage 2018;178:414-22.&#13;
16. Krishna V, Sammartino F, Rezai A. A review of the current therapies, challenges, and future directions of transcranial focused ultrasound technology: Advances in diagnosis and treatment. JAMA Neurol 2018;75:246-54.&#13;
17. Leinenga G, Langton C, Nisbet R, Gand;ouml;tz J. Ultrasound treatment of neurological diseases-current and emerging applications. Nat Rev Neurol 2016;12:161-74.&#13;
18. Piper RJ, Hughes MA, Moran CM, Kandasamy J. Focused ultrasound as a non-invasive intervention for neurological disease: A review. Br J Neurosurg 2016;30:286-93.&#13;
19. Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2016;375:730-9.&#13;
20. Abe K, Yamaguchi T, Hori H, Sumi M, Horisawa S, Taira T, et al. Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: A case report. BMC Neurol 2020;20:160.&#13;
21. Monteith S, Snell J, Eames M, Kassell NF, Kelly E, Gwinn R. Transcranial magnetic resonance-guided focused ultrasound for temporal lobe epilepsy: A laboratory feasibility study. J Neurosurg 2016;125:1557-64.&#13;
22. Juhand;aacute;sz C, John F. Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy. Seizure 2020;77:15-28.&#13;
23. Rosenow F, Land;uuml;ders H. Presurgical evaluation of epilepsy. Brain 2001;124:1683-700.&#13;
24. Zhang M, Liu W, Huang P, Lin X, Huang X, Meng H, et al. Utility of hybrid PET/MRI multiparametric imaging in navigating SEEG placement in refractory epilepsy. Seizure 2020;81:295-303.&#13;
25. Proudfoot M, Woolrich MW, Nobre AC, Turner MR. Magnetoencephalography. Pract Neurol 2014;14:336-43.&#13;
26. Lopes da Silva F. EEG and MEG: Relevance to neuroscience. Neuron 2013;80:1112-28.&#13;
27. Yin C, Zhang X, Chen Z, Li X, Wu S, Lv P, et al. Detection and localization of interictal ripples with magnetoencephalography in the presurgical evaluation of drug-resistant insular epilepsy. Brain Res 2019;1706:147-56.&#13;
28. Kharkar S, Knowlton R. Magnetoencephalography in the presurgical evaluation of epilepsy. Epilepsy Behav 2015;46:19-26.&#13;
29. Szaflarski JP. Magnetoencephalography and stereo-EEG unite! Epilepsy Curr 2017;17:86-7.&#13;
30. Youssofzadeh V, Agler W, Tenney JR, Kadis DS. Wholebrain MEG connectivity-based analyses reveals critical hubs in childhood absence epilepsy. Epilepsy Res 2018;145:102-9.&#13;
31. Wu C, Xiang J, Jiang W, Huang S, Gao Y, Tang L, et al. Altered effective connectivity network in childhood absence epilepsy: A multi-frequency MEG study. Brain Topogr 2017;30:673-84.&#13;
32. Gong Q, He Y. Depression, neuroimaging and connectomics: A selective overview. Biol Psychiatry 2015;77:223-35.&#13;
33. Strambo D, Rey V, Rossetti AO, Maeder P, Dunet V, Browaeys P, et al. Perfusion-CT imaging in epileptic seizures. J Neurol 2018;265:2972-9.&#13;
34. Austein F, Huhndorf M, Meyne J, Laufs H, Jansen O, Lindner T. Advanced CT for diagnosis of seizure-related stroke mimics. Eur Radiol 2018;28:1791-800.&#13;
35. Chang C, Huang C, Zhou N, Li SX, Ver Hoef L, Gao Y. The bumps under the hippocampus. Hum Brain Mapp 2018;39:472-90.&#13;
36. Van Cauwenberge MG, Dekeyzer S, Nikoubashman O, Dafotakis M, Wiesmann M. Can perfusion CT unmask postictal stroke mimics? A case-control study of 133 patients. Neurology 2018;91:e1918-27.&#13;
37. Abdulbaqi AS, Younis MT, Younus YT, Obaid AJ. A hybrid technique for EEG signals evaluation and classification as a step towards to neurological and cerebral disorders diagnosis. Int J Nonlinear Anal Appl 2022;13:773-81.&#13;
38. Gage G, Marzullo T. How Your Brain Works: Neuroscience Experiments for Everyone. United States: MIT Press; 2022.&#13;
39. Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, et al. Clinical proton MR spectroscopy in central nervous system disorders. Radiology 2014;270:658-79.&#13;
40. Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan EV, Lim KO. In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Arch Gen Psychiatry 1999;56:185-92.&#13;
41. Maudsley AA, Domenig C, Govind V, Darkazanli A, Studholme C, Arheart K, et al. Mapping of brain metabolite distributions by volumetric proton MR&#13;
spectroscopic imaging (MRSI). Magn Reson Med 2009;61:548-59.&#13;
42. Kirov II, Kuzniecky R, Hetherington HP, Soher BJ, Davitz MS, Babb JS, et al. Whole brain neuronal abnormalities in focal quantified with proton MR&#13;
spectroscopy Epilepsy Res 2018;139:85-91.&#13;
43. Maudsley AA, Domenig C, Ramsay RE, Bowen BC. Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy. Epilepsy Res 2010;88:127-38.</References>
      </References>
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