<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>isfcppharmaspire</PublisherName>
      <JournalTitle>Pharmaspire</JournalTitle>
      <PISSN>C</PISSN>
      <EISSN>o</EISSN>
      <Volume-Issue>Volume 15, Issue 04, 2023</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>October-December</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2024</Year>
        <Month>02</Month>
        <Day>17</Day>
      </PubDate>
      <ArticleType>Pharmacognosy</ArticleType>
      <ArticleTitle>In silico studies on Urtica dioica as aldose reductase inhibitors</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>221</FirstPage>
      <LastPage>224</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Megha</FirstName>
          <LastName>Goswami</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Priya</FirstName>
          <LastName>Bisht</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Ghanshyam Das</FirstName>
          <LastName>Gupta</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Sant Kumar</FirstName>
          <LastName>Verma</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI>10.56933/Pharmaspire.2023.15133</DOI>
      <Abstract>Urtica dioica L. is a perennial plant which is commonly known as “stinging nettle.” It is widely distributed throughout the temperate and tropical areas around the world. The genus Urtica is derived from word “uro” which means to burn or “urere” which means to sting. Due to the fact that the plant typically either has male or female blooms, the species name is dioica which means “two households”. Apart from various traditional uses, it is reported for the treatment of diabetes. Owing to the antioxidant potential and presence of flavonoids, here in this research, in silico studies has been performed on U. dioica to establish its target affinity against aldose reductase.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Aldose reductase, Diabetic complications, Molecular docking, Urtica dioica</Keywords>
      <URLs>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=15067&amp;title=In silico studies on Urtica dioica as aldose reductase inhibitors</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>1. Joshi BC, Kalia AN, Makhija M. Pharmacognostical review of Urtica dioica L. Int J Green Pharm 2014;4:201-209.&#13;
2. Taheri Y, Quispe C, Herrera-Bravo J, Sharifi-Rad J, Ezzat SM, Merghany RM, et al. Urtica dioica-derived phytochemicals for pharmacological and therapeutic applications. Evid Based Complement Alternat Med 2022;2022:4024331.&#13;
3. WHO monograph on selected medicinal plants. Radix Urticae 2002;2:329.&#13;
4. Qujeq D, Tatar M, Feizi F, Parsian H, Sohan Faraji A, Halalkhor S. Effect of Urtica dioica leaf alcoholic and aqueous extracts on the number and the diameter of the islets in diabetic rats. Int J Mol Cell Med 2013;2:21-6.&#13;
5. Kianbakht S, Khalighi-Sigaroodi F, Dabaghian FH. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: A randomized double-blind placebo-controlled clinical trial. Clin Lab 2013;59:1071-6.&#13;
6. Rahimzadeh M, Jahanshahi S, Moein S, Moein MR. Evaluation of alpha-amylase inhibition by Urtica dioica and Juglans regia extracts. Iran J Basic Med Sci 2014;17:465-9.&#13;
7. Keshvari M, Rahmati M, Mirnasouri R, Chehelcheraghi F. Effects of endurance exercise and Urtica dioica on the functional, histological and molecular aspects of the hippocampus in STZ-Induced diabetic rats. J Ethnopharmacol 2020;256:112801.&#13;
8. Fowler MJ. Microvascular and macrovascular complications of diabetes. Clin Diabetes 2011;29:116-122.&#13;
9. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev 2013;93:137-88.&#13;
10. Srivastava SK, Ramana KV, Bhatnagar A. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev 2005;26:380-92.&#13;
11. Kumar M, Choudhary S, Singh PK, Silakari O. Addressing selectivity issues of aldose reductase 2 inhibitors for the management of diabetic complications. Future Med Chem 2020;12:1327-58.&#13;
12. Gacche RN, Dhole NA. Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: An attempt to standardize the botanicals for amelioration of diabetes complications. Food Chem Toxicol 2011;49:1806-13.&#13;
13. Verma SK, Thareja S. An overview on chemistry of natural aldose reductase inhibitors for the management of diabetic complications. Stud Nat Prod Chem 2022;65:381-429.</References>
      </References>
    </Journal>
  </Article>
</ArticleSet>