<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>isfcppharmaspire</PublisherName> <JournalTitle>Pharmaspire</JournalTitle> <PISSN>C</PISSN> <EISSN>o</EISSN> <Volume-Issue>Volume 11, Issue 1</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>January-March, 2019</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Pharmaceutics</ArticleType> <ArticleTitle>Synthesis and biological evaluation of pyrazole clubbed pyrimidine bearing imidazole as linker for potent antioxidant agents</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>24</FirstPage> <LastPage>28</LastPage> <AuthorList> <Author> <FirstName>Sangh</FirstName> <LastName>Partap</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Md Jawaid</FirstName> <LastName>Akhtar</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Gourav</FirstName> <LastName>Grover</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Rajarshi</FirstName> <LastName>Nath</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>The promoted synthesis of novel compound 2-(4,5-bis(1-phenyl-3-(4-substitutedphenyl)- 1H-pyrazol-4-yl)-2H-imidazol-2-yl)pyrimidine incorporating three pharmacophoric heterocyclic was synthesized through one-pot reaction between pyrimidine-2- carboximidamide and 3-(4-substitutedphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde. Full assignment of all 1 H and 13C nuclear magnetic resonance chemical shifts has been unambiguously achieved. The proposed reaction mechanism is also discussed. Further, the synthesized compounds were evaluated for in vitro diphenyl-2-picryl-hydrazyl (DPPH) assay for antioxidant activity using ascorbic acid as standard. Compound 3b and 3e showed most promising antioxidant activity.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>1,1-biphenyl-2-picrylhydrazyl, pyrazole, pyrimidine, antioxidant</Keywords> <URLs> <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13873&title=Synthesis and biological evaluation of pyrazole clubbed pyrimidine bearing imidazole as linker for potent antioxidant agents</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>1. Somashekara B, Thippeswamy B, Vijayakumar GR. Synthesis, antioxidant and and;alpha;-amylase inhibition activity of naphthalene-containing 2, 4, 5-trisubstituted imidazole derivatives. J Chem Sci 2019;131:1-7. 2. Srinivasan N. Antioxidant potential and antimicrobial screening of some novel imidazole derivatives. J Biosci opin 2013;1:157-67. 3. El-Adasy AA. Synthesis, characterization, antioxidant and quantum chemical calculations of some new thiophene, diazepine and pyrimidine derivatives containing sulfamoyl moiety. Int J Chem Stud 2017;5:872-6. 4. Bundy GL, Ayer DE, Banitt LS, Belonga KL, Mizsak SA, Palmer JR, et al. Synthesis of novel 2,4-diaminopyrrolo [2, 3-d] pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J Med Chem 1995;38:4161-3. 5. Singh P, Kumar R, Tiwari S, Khanna RS, Tewari AK, Khanna HD. Docking, synthesis and evaluation of antioxidant activity of 2, 4, 5-triaryl imidazole. Clin Med Biochem 2015;1:1-4. 6. Nayak PS, Narayana B, Sarojini BK, Sheik S, Shashidhara KR, Chandrashekar KR. Design, synthesis, molecular docking and biological evaluation of imides, pyridazines, imidazoles derived from itaconic anhydride for potential antioxidant and antimicrobial activities. J Taibah Univ Sci 2014;10:823-38. 7. Singh P, Tiwari RK, Khanna RS, Tewari AK, Khanna HD. Docking, synthesis and evaluation of antioxidant activity of 2, 4, 5-triaryl imidazole. Clin Med Biochem 2015;1:1-4. 8. Satyanarayana VS, Rakshit M, Sivakumar A. Microwave-assisted synthesis of 2, 4, 5-triphenyl-1H-imidazole containing Schiff base derivatives with potential antioxidant and anticancer activities. Asian J Chem 2011;23:1212. 9. Lombardino JG, Wiseman EH. Preparation and anti-inflammatory activity of some nonacidic trisubstituted imidazoles. J Med Chem 1974;17:1182-8. 10. Sarala L, Merlin JP, Elanthamilan E. Catalyst free synthesis of imidazoles: Characterization and its antimicrobial activity. J Chem Pharm Res 2016;8:225. 11. Chandrashekaraiah M, Gowda VD, Lingappa M, Bhadregowda DG. Synthesis of some new pyrimidine-azitidinone analogues and their antioxidant, in vitro antimicrobial, and antitubercular activities. J Chem 2014;2014:1-9. 12. Kumari S, Narasimha B. Therapeutic potential of heterocyclic pyrimidine scaffolds. Chem Cent J 2018;12:38. 13. Kotb ER, Morsy EM, Anwar MM, El-Deen EM, Hanem, Awad M. New pyrimidine derivatives: Synthesis, antitumor and antioxidant evaluation. Int J Pharm Technol 2015;7:8061-85. 14. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad international steering committee. Stroke 2000;31:2257-65. 15. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, etal. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third national acute spinal cord injury randomized controlled trial. J Neurosurg 1998;89:699-706. 16. The RANTTAS Investigators. A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). Stroke 1996;27:1453-8. 17. Jagadish PC, Soni N, Verma A. Design, synthesis, and in vitro antioxidant activity of 1, 3, 5-trisubstituted-2-pyrazolines derivatives. J Chem 2013;2013:1-6. 18. Kumar A, Varadaraj BG, Singla RK. Synthesis and evaluation of antioxidant activity of novel 3, 5-disusbtituted-2-pyrazolines. Bull Fac Pharm 2013;51:167-73. 19. Shankar KR, Geetha K, Vaidehi BN. Synthesis, characterization and in vitro antioxidant, antimicrobial and anti-inflammatory activities of 2-aryl pyrazolines from Chalcones. Int J 2013;1:869-77. 20. Muneera MS, Joseph J. Design, synthesis, structural elucidation, pharmacological evaluation of metal complexes with pyrazoline derivatives. J Photochem Photobiol B 2016;163:57-68. 21. Reddy LS, Rajkumar T, Jyothi K, Reddy YS. Synthesis, characterization and anti-oxidant, anti-inflammatory activities of some novel chalcones and 1, 3, 5-trisubstituted pyrazolines. Pharm Sin 2015;6:73-82. 22. Akhtar MJ, Siddiqui AA, Khan AA, Ali Z, Dewangan RP, Pasha S, et al. Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors. Eur J Med Chem 2017;126:853-69. 23. Ali Z, Akhtar MJ, Siddiqui AA, Khan AA, Haider R, Yar MS. Design and synthesis of quinazoline-3, 4 (4H) diamine endowed with thiazoline moiety as new class for DPPIV and DPPH inhibitors. Bioorg Chem 2017;71:181-91. 24. Chhatbar P, Pambhar K, Khedkar V, Shah A, Khunt R. In silico (3D-QSAR) design, study, synthesis and anti-tubercular evaluation of pyrazolo-pyrimidine derivatives. Antiinfect Agents 2019;17:1-9</References> </References> </Journal> </Article> </ArticleSet>