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  <Article>
    <Journal>
      <PublisherName>isfcppharmaspire</PublisherName>
      <JournalTitle>Pharmaspire</JournalTitle>
      <PISSN>C</PISSN>
      <EISSN>o</EISSN>
      <Volume-Issue>Volume 10, Issue 1</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>January-March, 2018</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2022</Year>
        <Month>06</Month>
        <Day>14</Day>
      </PubDate>
      <ArticleType>Pharmaceutics</ArticleType>
      <ArticleTitle>Release kinetic study of enteric coating of senna tablet</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>29</FirstPage>
      <LastPage>40</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Ramchander Khatri</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Tanuj Hooda</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Rakesh Gupta</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Prashant Kumar</FirstName>
          <LastName/>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Pawan</FirstName>
          <LastName>Jawal</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>The development of enteric coated formulation has been one approach to preventing the drug from coming into contact with gastric mucosa. The enteric coating dosage form releases the drug after leaving the stomach. The results of this study indicate that enteric coated tablets using 12% cellulose acetate phthalate (CAP) are suitable for the senna drug which is mainly active in the lower Gastrointestinal track. The physical compatibility study at 40__degreesignC/75% RH showed that senna extract, ajowan oil, and excipients used during the research work found to be physically compatible. The tablet formulation was prepared by wet granulation technique, and the physical characteristics of granules were evaluated for moisture content (%), compressibility index, angle of repose, Hausner ratio and found to have good flow and compressibility. The tablet formulations developed were found to be within the limits with respect to in-process parameters such as thickness, hardness, friability, weight variation, and disintegration time. The different trail batches of enteric coated tablets were developed using a different percentage of CAP, and drug release profile of different batches were studies with the help of five kinetic models, namely zero order, first order, Higuchi, Hixon-crowell, and Korsmeyer-Peppas model. The entire kinetic models studied for all the batches of different concentration of CAP. The batch containing 4% CAP, it was observed that the batch followed zero-order kinetic model because of having maximum R2 value of 0.990. The batch having 8% CAP and it was observed that the batch followed zero-order kinetic model because of having maximum R2 value of 0.959. The batch having 12% CAP and it was observed that the batch followed Higuchi model because of having maximum R2 value of 0.999. The batch having 16% CAP and it was observed that the batch followed Hixon-Crowell model and Higuchi model both because of having maximum R2 value of 0.991. The batch having 20% CAP, it was observed that the batch followed zero-order kinetic and Higuchi kinetic model because of having maximum R2 value of 0.984. The batch having 24% CAP, it was observed that the batch followed Hixon-Crowell kinetic model because of having maximum R2 value of 0.981.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Senna, tablet, cellulose acetate phthalate, pharmacokinetic</Keywords>
      <URLs>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13847&amp;title=Release kinetic study of enteric coating of senna tablet</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>1. Latchman L, Lieberman HA, King JL. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1990. p. 297-321.&#13;
&#13;
2. Ansal H, Allen L Jr., Popovich N. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 8th ed. Baltimore, Md: Lippincott Williams and; Wilkins; 2005. p. 227-59.&#13;
&#13;
3. Vyas S, Khar R. Controlled Drug Delivery Concepts and Advances. 1st ed. New Delhi: Vallabh Prakashan; 2016. p. 219-256.&#13;
&#13;
4. Remington J. Remington: The Science and Practice of Pharmacy. 9th ed., Vol. II. Pennsylvania, USA: Mack Publishing Co.; 1615-1641.&#13;
&#13;
5. Gerhardt AH. Moisture effects on solid dosage forms formulation, processing and stability. J GXP Compliance Winter 2009;33:42-51.&#13;
&#13;
6. Aniruddha MR, Joseph BS. Evaluation and Comparison of a moist granulation technique to conventional methods. Drug Dev Ind Pharm 2000;26:885-9.&#13;
&#13;
7. Patil PS, Rajani S. An advancement of analytical techniques in herbal research. J Adv Sci Res ;1:8-14.&#13;
&#13;
8. Kalam MA. Release kinetics of modified pharmaceutical dosage form: A review. Cont J Pharm Sci 2010;1:30-5.&#13;
&#13;
9. Mulye NV, Turco SJ. A simple model based on first order kinetics to explain release of highly water soluble drugs from porous dicalcium phosphate dehydrate matrics. Drug Dev Ind Pharm 2007;21:943-53.&#13;
&#13;
10. Simon GL, Gorbach SL. Intestinal flora in health and disease. Gastroenterology 2010;68:174-93.&#13;
&#13;
11. Prasad YV, Krishnaiah YS, Satyanarayana S. In vitro evaluation of guar gum as carrier for colon-specific drug delivery. J Control Release 1995;51:281-7.&#13;
&#13;
12. Shukla AJ, Price JC. Effect of drug loading and molecular weight of cellulose acetate propionate on the release characteristics of theophylline microspheres. Pharm Res ;8:1369-400.&#13;
&#13;
13. Higuchi WI. Diffusional models useful in bio pharmaceutics drug release rate process. J Pharm Sci ;56:315-24.&#13;
&#13;
14. Noyes AA, Whitney WR. The rate of solution of solid substances in their own solution. J Am Chem Soc 1984;19:930-4.&#13;
&#13;
15. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm 1998;15:25-35.&#13;
&#13;
16. Shah SA, Ravishankara MN, Nirmal A, Shishoo CJ, Rathod IS, Suhagia BN. Estimation of individual sennosides in plant materials and marketed formulation by an HPTLC method. J Pharm Pharm 2000;52:445-9.&#13;
&#13;
17. Maitil B, Nagori BP, Singh R. Recent trend in herbal drugs: A review. Int J Drug Res Technol 2011;1:17-25.&#13;
&#13;
18. Patil SG. Standard tool for evaluation of herbal drugs: An overview. Pharm Innov J 2013;2:60.&#13;
&#13;
19. Atal CK, Kapoor BM. Cultivation and Utilization of Medicinal Plants. Jammu Twai, India: RRL 1982; . p. 8.&#13;
&#13;
20. Dutta A, De B. Seasonal variation in the content of sennosides and rhein in leaves and pod of Cassia fistula. Indian J Pharm Sci 1998;60:388-90.&#13;
&#13;
21. Hollenbeck RG, Mitrevej KT, Fan AC. Estimation of extent of drug-excipient interactions involving croscar mellose sodium. J Pharm Sci 1983;72:325-7.</References>
      </References>
    </Journal>
  </Article>
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