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<PublisherName>isfcppharmaspire</PublisherName>
<JournalTitle>Pharmaspire</JournalTitle>
<PISSN>C</PISSN>
<EISSN>o</EISSN>
<Volume-Issue>Volume 13, Issue 2</Volume-Issue>
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<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>April - June, 2021</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>2022</Year>
<Month>06</Month>
<Day>7</Day>
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<ArticleType>Pharmaceutics</ArticleType>
<ArticleTitle>Role and application of protein binding in drug distribution process</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>35</FirstPage>
<LastPage>41</LastPage>
<AuthorList>
<Author>
<FirstName>Lavisha</FirstName>
<LastName>Jindal</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Gurmeet</FirstName>
<LastName>Singh</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
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<DOI/>
<Abstract>The amount of drug which binds to proteins is considered protein-drug binding. The binding of drugs to protein is reversible and irreversible. Reversible generally involves a weak chemical bond. Irreversible arises due to covalent bonding. Irreversible binding can also occur because of carcinogenicity or tissue toxicity of the drug. The plasma protein binding to a drug has a significant role in the pharmacokinetics and pharmacodynamics of a drug. The amount of free active fraction of drug is determined by how much drug is bound to plasma protein. Protein binding to the drug can enhance or detract the drug’s efficiency. Protein binding can enhance the distribution of drugs throughout the body. It may also alter the duration of the action of the drug. Protein binding to drug alters therapeutic effect by forming a drug-protein complex which is itself biologically active. This review focuses on what is protein dug binding, how the protein binds to a drug. A description of the different methods used for determining protein-drug binding is also given. Protein-drug binding influences biological barriers, and how they cross them is also discussed. A discussion is also included to help readers to know the different factors affecting protein-drug binding.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Protein, plasma, DNA, metabolism, drug distribution</Keywords>
<URLs>
<Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13784&title=Role and application of protein binding in drug distribution process</Abstract>
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<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>1. Budhiraja RD. Elementary Pharmacology and Toxicology. General Principles of Pharmacology. Ch. 1. Maharashtra: Ramdas Bhatkal for Popular Parkashan; 2009. p. 1.
2. Tripathi KD. Essentials of medical pharmacology. In: Pharmacodynamics: Mechanism of Drug Action; Receptor Pharmacology. Ch. 4. Jaypee Brothers Medical Publishers; 2013. p. 19-20, 39-40.
3. Torreri P, Ceccarini M, Macioce P, Petrucci TC. Biomolecular interactions by surface plasmonresonance technology. Ann Ist Super Sanitand;agrave; 2005;41:437-41.
4. Agarwal SP, Rajesh K. Physical pharmacy. In: Complexation and Protein Binding. Ch. 7. New Delhi: CBS Publishers and Distributors; 2006. p. 208-14.
5. Michel Bteich. An Overview of Albuminandand;alpha;1 -Acidglycoprotein Main Characteristics: Highlighting the Roles of Amino Acids Inbinding Kinetics and Molecular Interactions. Amsterdam, Netherlands: Elsevier; 2019. p. e02879.
6. Schefie RT. Protein binding: What does it mean? DICP 1989;23:27-31.
7. Karine V, Julie S, Jean-Luc V, Pierre-Alain C, Sophie M. Drug-protein Binding: A Critical Review of Analytical Tolls. Berlin, Germany: Springer-Verlag; 2010.
8. Karolina W. Biological Barriers, and the Influence of Protein Binding on the Passage of Drug Across them. Molecular Biology Reports; 2020.
9. Wright JD, Boudinot FD, Ujhelyi MR. Measurement and analysis of unbound drug concentrations. Clin Pharmacokinet 1996;30:445-62
10. Kok-Yong S, Lawrence L. Drug distribution and drug elimination. In: Ahmed TA, editor. Basic Pharmacokinetics Concepts and Some Clinical Applications. London: IntechOpen; 2015. p. 5772-9929.
11. Lazaro E, Lowe PJ, Briand X, Faller B. New approach tomeasure protein binding based on a parallel artificial membrane assay and human serum albumin. J Med Chem 2008;51:2009-17.
12. Kansy M, Senner F, Gubernator K. Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description assay in the description of passive absorption processes. J Med Chem 1998;41:1007-10.
13. Hage DS, Tweed SA. Recent advances in chromatoghraphic and electrophoretic methods for the study of drug-protein intracyion. J Chromatogr B 1997;699:499-525.
14. Heegaard NH, Nilsson S, Guzman NA. Affinity capillary electrophoresis: Important applications areas and somerecent developments. J Chromatogr B 1998;715:29-54.
15. Gullo VP, Hughes DE. Exploring new approaches for natural product drug discovery in the biotechnology industry. Drug Discov Today Technool 2005;2:281-6.
16. Bush MH, Kraak JC, Poppe H. Principles and limitations of methods available for the determination of binding constants with affinity capillary electrophoresis. J Chromatogr A 1997;777:329-53.
17. Oravcova J, Bohs B, Linder W. Drug-protein binding studies-new trends in analytical and experimental metholodgy. J Chromatogr B 1983;677:1-28.
18. Liu YC, Yang ZY, Du J, Yao XJ, Lei RX, Zheng XD, et al. Study on the interactions of kaempferol and quercetin with intravenous immunoglobulin by fluorescence quenching. Fourier transformation infrared spectroscopy and circular dichrosim spectroscopy. Chem Pharm Bull 2008;56:443-51.
19. Velazquez-Campoy A, Ohtaka H, Nezami A, Muzammil S, Velazquez-CampoyA, Leavitt SA, et al. Characterization of protein-protein interactions by isothermal titration calorimetry. In: Protein-Protein Interactions. 2004. p. 35-54.
20. Freire E. Isothermal titration calorimetry. Curr Protoc Cell Biol 2004;17:1-24.
21. Plotnikov V, Rochalski A, Brandts M, Brandts JF, Williston S, Frasca V, et al. An auto sampling differential scanning calorimeter instrument for studying molecular interactions. Assay Drug Dev Technol 2002;1:83-90
22. He YL, Tsujiomoto S, Tanimoto M, Okutani R, Murakawa K, Tashiro C. Effects of protein binding on the planceta transfer of propofol in the human dually perfused cotyledon in vitro. Br JAnaesth. 2000;85:281-6.
23. Cross SE, Roberts MS. Targeting local tissues by transdermal application: Understanding drug physciochemical properties that best exploit protein binding and blood flow effects. Drug Dev Res 1999;46:309-15.
24. Benfeldt E, Serup J, Menne T. Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: In vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Br J Dermatol 1999;140:739-48.
25. Dalvi UG, Zatz JL. Effect of skin binding on percutaneous transport of bezoacine from aqueous suspension and solution. J Pharm Sci 1982;71:824-6.
26. Le J. Drug Distribution to Tissues. MSD Manual; 2020.
27. Lakshmana SP, Suriyaprakash TN, Ruckmani K, Thirumurugan R. Biopharmaceutics and pharmacokinetics. In: Ahmed TA, editor. Basic Pharmacokinetics Concepts and Some Clinical Applications. Vol. 10. London: IntechOpen; 2015. p. 5772-61160.
28. Hoffman A, Danenberg HD, Katzhendler I, Shuval R, Gilhar D, Friedman M. Pharmacodynamic and pharmacokinetics rationales for the development of an oral controlled-release amoxicillin dosage form. J Control Release 1998;54:29-37.
29. Stempel E. Prolonged drug action. J Am Pharm Assoc 1959;20:0095-9561
30. Bohnert T, Liang-Shang G. Plasma protein binding: From discovery to development. J Pharm Sci 2013;102:2953-94.
31. Masaki O. Study on binding of drug to serum protein.Yakugaku Zasshi 2009;129:413-25.
32. Christine T, Anastasia A. The role of protein binding on the mode of drug action as well the interactions with other drugs. Eur J Drug Pharmacokinet 2008;33:225-30.
33. Caterina P, Di Paolo A, Luca G. Pharmacokinetics drug-drug interaction and their implication in clinical management. J Res Med Sci 2013;18:601-10. 34. David RT. Drug excretion. In: Pharmacology. ScienceDirect; 2009.
35. Laznicek M, Laznicokva A. The effect of lipophilicity on the protein binding and blood cell uptake of some acidic drugs. J Pharm Biomed Anal 1995;13:823-8.
36. Mohamed LS, Cathy JP. Interpreting and utilizing intersubject variability in brain function. Trends Cogn Sci 2018;10:1016.
37. Amy SC. Preventing healthcare-associated infections. In: Hughes RG, editor. Patient Safety and Quality: An Evidence-based Handbook for Nurses. Rockville; Agency for Healthcare Research and Quality; 2008.
38. Lidia JN. Plasma protein binding of drugs in pregnancy and in neonates. Clin Pharmacokinet 2012;18:20-36.
39. Vogler C, Bove KE. Morphology of skeletal muscle in children. An assessment of normal growth and differentiation. Arch Pathol Lab Med 1985;109:238-42.
40. Tillement JP, Lhoste F, Giudicell JF. Disease and drug protein binding. Clin Pharmacokinect 1978;3:144-54.
41. Verena G, Rishik V, Ishwarlal J. Hypoalbuminemia. StatPearls; 2020.
42. Cebra Christopher and Cebra Margaret. Disease In cardiovascular System. Sheep and Goat Medicine; 2012.
43. Pardridge WM, Connor JD, Crawford IL. Permeability changes in the blood-brain barrier: Causes and consequences. CRC Crit Rev Toxicol 1975;3:159-99.
44. Clarke KW, Trim CM, Hall LW. Patient monitoring and clinical measurement. In: Veterinary Anaesthesia. 11th ed. Philadelphia, PA: WB Saunders; 2014. p. 19-63
45. Mooradian AD. An update of clinical pharmacokinetics, therapeutics monitoring techniques and treatment recommendations. Clin Phamacokinet 1998;10:2165.</References>
</References>
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