PHARMASPIRE - Volume 14, Issue 04 , 2022 , October-December
Pages: 154-166
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Nanocarrier based drug delivery system – Future of Alzheimer disease
Author: Sharma Jyoti, Gupta Sunil, Sharma Amit, Sharma Nitin
Category: Pharmaceutics
Abstract:
Alzheimer’s disease (AD) has risen to the top most cause of mortality in the world. Every twenty years, the illness rate doubles, affecting about one in every 10 households. AD is characterized by a gradual loss of neurons in the cerebral cortex, resulting in brain shrinkage. Senile neuritic plaques and neurofibrillary tangles become the disease’s primary characteristic. However, a continuous strategy is customized to cure AD effectively. However, as a result of difficulties in the medication delivery system induced by different barriers such as blood–brain barrier and cerebrospinal fluid has become the primary cause of therapeutic failure. Thus, to address these problems, nanotechnology is a potential technique for overcoming them. This study discusses the use of targeted delivery of medicament for the successful remedy and diagnosis of AD that utilizes nanocarriers as an alternative administration route, thus allowing the release of the drug intocentral nervous system.
Keywords: Dementia, Alzheimer’s disease, Nanocarriers, Blood brain barrier, Targeted drug delivery
DOI: 10.56933/Pharmaspire.2022.14220
DOI URL: https://doi.org/10.56933/Pharmaspire.2022.14220
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