PHARMASPIRE - Volume 10, Issue 4, October - December, 2018
Pages: 164-166
Date of Publication: 14-Jun-2022
Print Article
Download XML Download PDF
Diclofenac-induced hypersensitivity reaction in a patient suffering from rheumatoid arthritis: A case report
Author: Gurpreet Kaur, Kusheshwar Prasad Singh, Ann Merin Saji, Aseem Sethi, Amit Sharma
Category: Pharmaceutics
Abstract:
Hypersensitivity reactions against nonsteroidal anti-inflammatory drugs like diclofenac (DF) can manifest as Type-I-like allergic reactions including systemic anaphylaxis. Angioedema is a transient subcutaneous or submucosal swelling that is non-pitting when pressure is applied. This case report was collected in the outpatient department of the tertiary care hospital in Punjab. This included a female patient who was having a hypersensitivity reaction on administering drug DF. The patient was diagnosed with drug-induced angioedema of the arm and was asked to discontinue the drug. Complete remission was seen after 1 week of discontinuing the medication.
Keywords: Angioedema, hypersensitivity reaction, nonsteroidal anti-inflammatory drugs
References:
1. Sharma A, Baldi A, Sharma DK. Drug induced generalized skin eruption in a diabetes mellitus patient receiving a metformin plus simvastatin in a tertiary care teaching hospital in Punjab. Curr Res Diabetes Obes J 2017;4:4-6.
2. Kushawaha SK, Sharma A, Ralta A, Sharma R, Raj D. Pharmacovigilance study: Drugs used in the treatment of tuberculosis at civil hospital Rohru (Shimla), Himachal Pradesh. Int J Adv Case Rep 2014;1:37-41.
3. Sharma A, Baldi A, Sharma DK. Drug utilization study at tertiary care hospitals in punjab. Adv Res Gastroenterol Hepatol 2017;7:101-5.
4. Sharma A, Baldi A, Sharma DK. Assessment of drug-related problems among diabetes and cardiovascular disease patients in a tertiary care teaching hospital. Pharm Aspire 2018;10:7-12.
5. Sharma A. Socio-demographic characteristics and drug related problems of patients presenting to the emergency department: General linear model and factorial analysis. J Pharm Care Health Syst 2018;5:1-6.
6. Edwards IR, Aronson JK. Adverse drug reactions: Definitions, diagnosis, and management. Lancet 2000;356:1255-9.
7. Baxter K, Sharp JM. Adverse drug interactions. Adv Drug React Bull 2008;248:952-4.
8. Waheed A, Hill T, Dhawan N. Drug allergy. Prim Care 2016;43:393-400.
9. Nayak S, Acharjya B. Adverse cutaneous drug reaction. Indian J Dermatol 2009;53:2-8.
10. Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005;5:309-16.
11. Bircher AJ. Drug hypersensitivity. Chem Immunol Allergy 2014;100:120-31.
12. Feinberg SM. Acute hypersensitivity reactions. In: Disease-a-Month. Chicago: Year Book Medical;1965.
13. Dwivedi M, Sharma A, Arora S. A review on medication errors. J Pharm Technol Res Manag 2015;3:89-96.
14. Sharma A, Kaur T, Vishal B, Rathore MS, Chhabra M, Gaur A. Drug utilization study on oral hypertensive medication patients and assessment of medication adherence to JNC-8 guidelines in North Indian tertiary care hospital: A crosssectional study. Open Hypertens J 2018;10:3-9.
15. Joshi N, Sharma A, Baldi A, Sharma DK. Drug utilization study in patients attending emergency department at a tertiary care hospital in Punjab: A prospective observational study. Pharmaspire 2018;10:95-7.
16. Holguín-Gómez L, Vásquez-Ochoa LA, Cardona R. Angioedema. Rev Alerg Mex 2016;63:373-84.
17. Lee A, Thomson J. Drug-induced skin reactions. Pharm J 1999;262:357-62.
18. Shaath TS, Patel VK, Rajpara AN, Fraga GR, Aires DJ. Drug-induced urticaria. In: Cutaneous Drug Eruptions: Diagnosis, Histopathology and Therapy. London: Springer; 2015.
19. Kavanagh A, Shields M. Drug reactions. In: Anaesthetic and Perioperative Complications. United Kingdom: Cambridge University Press; 2011.
20. Miller SM, Cumpston KL. Diphenhydramine. In: Encyclopedia of Toxicology. 3rd ed. Amsterdam: Academic Press; 2014.
21. Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, et al. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Arch Gen Psychiatry 1996;53:117-28.
22. Bird PA, Murray DP, Zhang M, Begg EJ. Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph. Otol Neurotol 2011;32:933-6.
23. Wyns H, Meyer E, Watteyn A, Plessers E, De Baere S, De Backer P, et al. Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in pigs. Vet J 2013;198:286-8.
24. Oakley GM, Harvey RJ. Topical steroids. Adv Otorhinolaryngol 2016;79: 121-30.
25. Sharma A, Baldi A, Sharma DK, Singh R, Anghore D. Fluoroquinolone (levofloxacin) induced tendinopathy with partial tearing of the achilles tendon-a case report. J Clin Case Stud 2017;2:2-5.
|