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PHARMASPIRE - Volume 11, Issue 1, January-March, 2019

Pages: 24-28
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Synthesis and biological evaluation of pyrazole clubbed pyrimidine bearing imidazole as linker for potent antioxidant agents

Author: Sangh Partap, Md Jawaid Akhtar, Gourav Grover, Rajarshi Nath

Category: Pharmaceutics


The promoted synthesis of novel compound 2-(4,5-bis(1-phenyl-3-(4-substitutedphenyl)- 1H-pyrazol-4-yl)-2H-imidazol-2-yl)pyrimidine incorporating three pharmacophoric heterocyclic was synthesized through one-pot reaction between pyrimidine-2- carboximidamide and 3-(4-substitutedphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde. Full assignment of all 1 H and 13C nuclear magnetic resonance chemical shifts has been unambiguously achieved. The proposed reaction mechanism is also discussed. Further, the synthesized compounds were evaluated for in vitro diphenyl-2-picryl-hydrazyl (DPPH) assay for antioxidant activity using ascorbic acid as standard. Compound 3b and 3e showed most promising antioxidant activity.

Keywords: 1, 1-biphenyl-2-picrylhydrazyl, pyrazole, pyrimidine, antioxidant


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