PHARMASPIRE - Volume 11, Issue 1, January-March, 2019
Pages: 14-17
Date of Publication: 14-Jun-2022
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Design, synthesis, and evaluation of pyrimidine bridged chalcone derivatives of naphthalene as antibacterial agents
Author: Bhupinder Kumar, Gurpreet Singh
Category: Pharmaceutics
Abstract:
Pyrimidines, due to their very distinct and unique place in our lives, have provoked significant interest of medicinal chemists in the development of novel antibacterial agents. Thus, with the aim to discover new potentially active antibacterial agents, we have synthesized some new pyrimidine bridged chalcone derivatives of naphthalene and investigated their antimicrobial activities against pathogenic microbial strains, Bacillus subtilis (MTCC 2451), Pseudomonas aeruginosa (MTCC 2642), and Escherichia coli (MTCC 82) by disk diffusion method. The compounds were found to possess moderate activity against all tested strains. In general, the new synthesized compounds showed a good antimicrobial activity against these microorganisms.
Keywords: Antibacterial, pyrimidine derivatives, chalcone, naphthalene derivatives
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