PHARMASPIRE - Volume 11, Issue 2, April - June, 2019

Pages: 38-42

Date of Publication: 14-Jun-2022

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Preparation and characterization of tinidazole-β-cyclodextrin inclusion complex

Author: Sukhbir Kaur, Daisy Arora, Bharat Khurana, Gurmeet Singh

Category: Pharmaceutics

Abstract:

Aim: Preparation and Characterization of Tinidazole-β-Cyclodextrin Inclusion Complex to increase the aqueous solubility and bioavailability of Tinidazole (TNZ) is an anti-protozoal drug. Method: TNZ was complexed with β-cyclodextrin (β-CD) by kneading method in 1:1 molar ratio in order to improve aqueous solubility and bioavailability of TNZ. The complex formation was determined by phase solubility measurements, obtaining AL type of diagram. Prepared complexes were characterized by Fourier transform infrared spectroscopy (FTIR), 1 H - Nuclear Magnetic Resonance (1 H-NMR). Results: The phase solubility diagram of tinidazole with β-CD in selected concentration range displayed AL type of diagram i.e. solubility of tinidazole was increased with increase in β-CD concentration under the concentration range that was tested. The in-vitro studies appraised of an increased solubility and dissolution rate of TNZ on complexation with β-CD as compared to TNZ alone. Conclusion: The complex prepared by kneading method in 1:1 molar ratio demonstrated notable increase in aqueous solubility and dissolution rate.

Keywords: Tinidazole, ?-cyclodextrin, Fourier transform infrared, differential scanning calorimetry, phase solubility, inclusion complex

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