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PHARMASPIRE - Volume 11, Issue 2, April - June, 2019

Pages: 34-37

Date of Publication: 14-Jun-2022

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Basic concepts of bigels

Author: Manu Singhai, Sankha Bhattacharya

Category: Pharmaceutics


The current learning describes the synthesis of innovative bigels as delivery matrices for controlled delivery applications. Since the past few years, many literatures are reviewed for pharmaceutical and cosmetic application focused on the controlled delivery of both lipophilic and hydrophilic active agents. Biphasic systems formed by water-based hydrogels and oil-based organogels are referred as Bigels. The bigels were prepared by mixing agar hydrogel and oleogel (stearyl alcohol) in different proportions. A deeper knowledge of the relationship between macroscopic properties and microscopic parameters seems necessary to aim at designing materials with specific rheological properties and suitable for specific uses. These formulations possess characteristics of both gels such as the cooling effect, enhancement of hydration of the stratum corneum, moisturizing effect, easily spreadable, and emollients application to the skin. The use of two gel systems in bigels can produce a synergetic effect such as enhancement of hydration of stratum corneum and drug penetration due to the presence of both water phase and oil phase. The suitability of the formulations for controlled drug release applications was thoroughly examined using microscopy, Fourier-transform infrared spectroscopy, as well as mechanical, electrical, thermal, drug release, and antimicrobial studies. At present, bigels are being widely explored as potential matrices for controlled drug delivery. In this article an attempt was made to highlight bigels and its characteristics. Nevertheless, newer therapeutic applications of bigels were also been discussed in our compilation.

Keywords: Innovative bigels, two-phase systems, hydrogels, organogels, characteristics, macroscopic properties, microscopic parameters, controlled delivery systems, applications


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