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PHARMASPIRE - Volume 11, Issue 3, July - September, 2019

Pages: 83-87

Date of Publication: 14-Jun-2022


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Development and characterization of clobetasol propionate loaded nanoemulgel for management of psoriasis

Author: Ankita Dadwal, Raj Kumar Narang

Category: Pharmaceutics

Abstract:

The aim of the present study is to formulate clobetasol propionate loaded nanoemulgel for the treatment of plaque psoriasis. Homogenization method is used for the formulation of nanoemulgel and prepared formulation was characterized on the basis of size, entrapment efficiency, polydispersity index, viscosity, spreadability, zeta potential, % in vitro release, in vitro skin permeation, and retention studies. The optimized formulation of nanoemulgel (F2) has shown the significant sustained release of clobetasol propionate.

Keywords: Nanoemulgel, nanoemulsion, permeation, retention, sebaceous gland

References:

1. Afifi T, de Gannes G, Huang C, Zhou Y. Topical therapies for psoriasis: Evidencebased review. Can Fam Phys 2005;51:519-25.

2. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007;445:866-73.

3. Mazzotta A, Esposito M, Carboni I, Schipani C, Chimenti S. Clobetasol propionate foam 0.05% as a novel topical formulation for plaque-type and scalp psoriasis. J Dermatol Treat 2007;18:84-7.

4. Decroix J, Pres H, Tsankov N, Poncet M, Arsonnaud S. Clobetasol propionate lotion in the treatment of moderate to severe plaque-type psoriasis. Cutis 2004;74:201-6.

5. Schäfer-Korting M, Kleuser B, Ahmed M, Höltje HD, Korting HC. Glucocorticoids for human skin: New aspects of the mechanism of action. Skin Pharmacol Physiol 2005;18:103-14.

6. Katare OP, Raza K, Singh B, Dogra S. Novel drug delivery systems in topical treatment of psoriasis: Rigors and vigors. Indian J Dermatol Venereol Leprol 2010;76:612.

7. Nakaguma H, Kambara T, Yamamoto T. Rat ultraviolet ray B photodermatitis: An experimental model of psoriasis vulgaris. Int J Exp Pathol 1995;76:65.

8. Singhal M, Kansara N. Cassia tora Linn cream inhibits ultraviolet-B-induced psoriasis in rats. ISRN Dermatol 2012;2012:346510.

9. (a) Aljuffali IA, Sung CT, Shen FM, Huang CT, Fang JY. Squarticles as a lipid nanocarrier for delivering diphencyprone and minoxidil to hair follicles and human dermal papilla cells. AAPS J 2014;16:140-50; (b) Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: Potential uses in cosmetic dermatology. Molecules 2009;14:540-54.

10. Radhika PR, Guruprasad S. Nanoemulsion based emulgel formulation of lipophilic drug for topical delivery. Int J PharmTech Res 2016;9:210-23.

11. Desai KG. Enhanced skin permeation of rofecoxib using topical microemulsion gel. Drug Dev Res 2004;63:33-40.

12. Jones DS, Woolfson AD, Brown AF. Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels. Pharm Res 1997;14:450-7.

13. Reddy MS, Mutalik S, Rao GV. Preparation and evaluation of minoxidil gels for topical application in alopecia. Indian J Pharm Sci 2006;68:432-6.

14. Shivhare U, Jain K, Mathur V, Bhusari K, Roy A. Formulation development and evaluation of diclofenac sodium gel using water soluble polyacrylamide polymer. Dig J Nanomater Biostruct 2009;4:285-90.

15. Begur M, Pai KV, Gowda D, Srivastava A, Raghundan H. Development and characterization of nanoemulgel based transdermal delivery system for enhancing permeability of tacrolimus. Adv Sci Eng Med 2016;8:324-32.

16. Gordon ML. The role of clobetasol propionate emollient 0.05% in the treatment of patients with dry, scaly, corticosteroid-responsive dermatoses. Clin Ther 1998;20:26-39.

17. Feldman SR. Relative efficacy and interchangeability ofvarious clobetasol propionate vehicles in the management of steroid-responsive dermatoses. Curr Ther Res Clin Exp 2005;66:154-71.