PHARMASPIRE - Volume 11, Issue 3, July - September, 2019
Pages: 69-75
Date of Publication: 14-Jun-2022
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Nanoparticles as carrier for oral drug delivery system
Author: Harmandeep Kaur, Amandeep Singh, Karishma Aggarwal
Category: Pharmaceutics
Abstract:
Due to the non-targeted drug delivery systems, various types of side effects are observed, in case of nanoparticle (NP), it acts as boom form the management of various diseases, with negligible side effects with maximum bioavailability of the drugs. However, many biological therapeutics that have poor solubility, poor permeability, or poor stability in the gastrointestinal environment include poor oral bioavailability and are consequently rarely used for oral drug delivery. Oral route is most frequent used method for drug delivery. In this paper, we have tried to cover the various nanocarriers for oral drug delivery system also brief about the challenge in drug delivery system such as dendrimers, liposomes, solid lipid nanocarriers, micelles, and polymeric NPs. These nanocarriers have been tailored as per the need of the disease for obtaining cellular level such as pH and presence of enzymes. The advantages of novel drug delivery carrier system over conventional drugs have been discussed, last discussed about Food and Drug Administration approved medicine as nanocarrier.
Keywords: Oral drug delivery system, novel drug delivery system, control release, sustained release
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