PHARMASPIRE - Volume 11, Issue 3, July - September, 2019
Pages: 79-82
Date of Publication: 14-Jun-2022
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Evaluation of the anxiolytic activity of methanolic extract of Skimmia anquetilia leaves
Author: Vijender Kumar, Viney Chawla, Poonam Verma, Baljinder Singh, Z. A. Bhat
Category: Pharmaceutics
Abstract:
Anxiolytic effects of methanolic extract of Skimmia anquetilia leaves have been assessed by elevated plus-maze test and light-dark arena test. Oral treatment with single doses of 100, 200, and 400 mg/kg body weight of this extract significantly increased the time spent and arm entries into open arms of the elevated plus-maze versus control group. In the light-dark arena test, extract doses were able to increases the percentage of time spent in the light compartment, as similar to standard drug that indicating significant anxiolytic effect. These results provide S. anquetilia leaves as dose-dependent anxiolyticlike effect in rats and support its potential remedy for the treatment of anxiety.
Keywords: Skimmia anquetilia, anxiolytic, elevated plus-maze, light-dark arena test
References:
1. Cheng B, Sheen LY, Chang ST. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. J Tradit Complement Med 2015;5:27-34.
2. Kumar V, Viney I, Chashoo A, Bhat ZA. Physicochemical and preliminary phytochemical standard of leaves of Skimmia anquetilia. Int J Bot Stud 2018;3:190-3.
3. Verma P, Singh B, Kaur A, Kumar V. In-vitro anti-inflammatory and antiarthritic activities of ethyl acetate extract of Skimmia anquetilia leaves. J Med Herb Ethnomed 2020;6:42-4.
4. Pellow S, Chopin P, File SE, Briley M. Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Meth 1985;14:149-67.
5. Bourin M, Petit-Demouliere B, Dhonnchadha BN, Hascoet M. Animal models of anxiety in mice. Fundam Clin Pharm 2007;21:567-74.
6. Belzung C. Measuring: Rodent exploratory behavior. In: Handbook of Molecular Genetics for Brain and Behavior Research. Amsterdam, Netherlands: Elsevier; 1999. p. 77-99.
7. Belzung C, Griebel G. Measuring normal and pathological anxiety-like behaviour in mice: A review. Behav Brain Res 2001;125:141-9.
8. Crawley JN. Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol Biochem Behav 1981;15:695-9.
9. Hossain M, Hasan SM, Mukta M, Akter R, Mazumder ME, Faruque A, et al. Anxiogenic activity of methanol extracts of Artocarpus lacucha Buch. Ham fruit parts and leaf in mice. Eur J Sci Res 2010;46:592-603.
10. Blanco MM, Costa CA, Freire AO, Santos JG, Costa M. Neurobehavioral effects of essential oil of Cymbopogon citrates in mice. Phytomed 2009;16:256-70.
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