PHARMASPIRE - Volume 11, Issue 3, July - September, 2019

Pages: 79-82

Date of Publication: 14-Jun-2022

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Evaluation of the anxiolytic activity of methanolic extract of Skimmia anquetilia leaves

Author: Vijender Kumar, Viney Chawla, Poonam Verma, Baljinder Singh, Z. A. Bhat

Category: Pharmaceutics

Abstract:

Anxiolytic effects of methanolic extract of Skimmia anquetilia leaves have been assessed by elevated plus-maze test and light-dark arena test. Oral treatment with single doses of 100, 200, and 400 mg/kg body weight of this extract significantly increased the time spent and arm entries into open arms of the elevated plus-maze versus control group. In the light-dark arena test, extract doses were able to increases the percentage of time spent in the light compartment, as similar to standard drug that indicating significant anxiolytic effect. These results provide S. anquetilia leaves as dose-dependent anxiolyticlike effect in rats and support its potential remedy for the treatment of anxiety.

Keywords: Skimmia anquetilia, anxiolytic, elevated plus-maze, light-dark arena test

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