PHARMASPIRE - Volume 11, Issue 4, October - December, 2019
Pages: 128-130
Date of Publication: 14-Jun-2022
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Some chalcone derivatives as antimicrobial agents: Synthesis and characterization
Author: Ashok Maddheshiya, Pooja Chawla
Category: Pharmaceutics
Abstract:
Substituted chalcones were synthesized by condensing benzaldehyde derivatives with acetophenone derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen–Schmidt condensation. In the presence of NaOH/ EtOH as a catalyst, various substituted chalcones are synthesized. The reaction is clean with excellent yield. The structures of the synthesized compounds were confirmed by IR and mass spectroscopy.
Keywords: Chalcone, Claisen–Schmidt condensation, aldehydes, antimicrobial
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