PHARMASPIRE - Volume 11, Issue 4, October - December, 2019

Pages: 124-127
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Synthesis and in vitro evaluation of silica-based formulations

Author: Hem Raj Heer, Vishav Prabhjot Kaur, Raj Kumar Narang, Charan Singh

Category: Pharmaceutics

Abstract:

Background: The cytotoxicity of the silica-based nanoformulations was investigated using non small cell human lung cancer cell line and RAW 264.7 macrophages cell line. Method: The formulations were exposed for 24 h at different dosage levels. 3-[4, 5-dimethylthiazol2-yl]-2, 5-diphenyl tetrazolium bromide assay was used to assess the cell response to the each formulation. Results: The formulations were found to have non-toxic in nature. Conclusion: These nanoformulations could be potentially used for delivering therapeutics for improved biopharmaceutical attributes.

Keywords: Cell line, cell viability, chitosan, cytotoxicity, porous aggregated nanoparticles

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