PHARMASPIRE - Volume 10, Issue 1, January-March, 2018
Pages: 07-12
Date of Publication: 14-Jun-2022
Print Article
Download XML Download PDF
Assessment of drug-related problems among diabetes and cardiovascular disease patients in a tertiary care teaching hospital
Author: Amit Sharma, Ashish Baldi , Dinesh Kumar Sharma
Category: Pharmaceutics
Abstract:
Drug-related problems (DRPs) are common in hospitalized patients and may lead to increase hospital stay, health-care cost, and augment the risk of morbidity and mortality. The aim of this study was to assess the prevalence of DRP and associated factors among medical ward patients in three different tertiary care teaching hospitals in Punjab, India. This study shows the evaluation of current prescribing pattern to identify different adverse drug reactions, specific drug-drug, drug-food interactions, and medication errors. The study was conducted at the Department of Medicine in three different hospitals setting in the Moga, District of Punjab, India. Based on the inclusion and exclusion criteria, the patient’s after signing the informed consent form data was collected from the patient case file, case reports, and laboratory reports. A total of 1230 cases were followed and reviewed in the medicine department during the study. Of the cases reviewed, 353 (78.27%) DRPs were identified from 451 patients. Of 451 patients, 256 (56.76%) were male and 195 (43.23%) were female. In this study, it was found that DRPs were identified in 451 patients. In which, drug interactions were maximum 252 (55.88%) followed by adverse reactions 106 (23.50%). The present study highlights the fact that clinical pharmacist can play a very important role in healthcare management by rationalizing and optimizing the drug therapy to achieving better quality of life.
Keywords: Adverse drug reactions, drug interactions, drug-related problems, drug use evaluation, inappropriate prescribing, medication error
References:
1. Huri HZ, Wee HF. Drug-related problems in Type 2 diabetes patients with hypertension: A cross-sectional retrospective study drug-related problems in Type 2 diabetes patients with hypertension: A cross-sectional retrospective study. BMC Endocr Disord 2013;13:1.
2. Horvat N, Kos M. Development and validation of the Slovenian drug-related problem classification system based on the PCNE classification V 6.2. Int J Clin Pharm 2016;38:950-9.
3. Pharmaceutical Care Network Europe Foundation. PCNE Classification of drug-related problems. Tidsskr Nor Laegeforen 2007;127:3073-6.
4. Maes KA, Tremp RM, Hersberger KE, Lampert ML. GSASA working group on clinical pharmacy, demonstrating the clinical pharmacists activity: Validation of an intervention oriented classification system. Int J Clin Pharm 2015;37:1162-71.
5. Lampert ML, Kraehenbuehl S, Hug BL. Drug-related problems: Evaluation of a classification system in the daily practice of a swiss university hospital. Pharm World Sci 2008;30:768-76.
6. Güemes Artiles M, Sanz Alvarez E, Garcia Sánchez-Colomer M. Adverse reactions and other drug-related problems in an emergency service department. Rev Esp Salud Publica 1999;73:511-8.
7. Spollett G. Case study : A patient with uncontrolled Type 2 diabetes and complex comorbidities whose diabetes care is managed by an advanced practice nurse. Diabetes Spectr 2003;16:32-6.
8. Eichenberger PM, Lampert ML, Kahmann IV, van Mil JW, Hersberger KE. Classification of drug-related problems with new prescriptions using a modified PCNE classification system. Pharm World Sci 2010;32:362-72.
9. Kempen TG, van de Steeg-van Gompel CH, Hoogland P, Liu Y, Bouvy ML. Large scale implementation of clinical medication reviews in dutch community pharmacies: Drug-related problems and interventions. Int J Clin Pharm 2014;36:630-5.
10. Nishtala PS, McLachlan AJ, Bell JS, Chen TF. A retrospective study of drug-related problems in australian aged care homes: Medication reviews involving pharmacists and general practitioners. J Eval Clin Pract 2011;17:97-103.
11. Rajaei-Dehkordi Z, MacPherson G. Drug-related problems in older people. Nurs Times 1997;93:54-6.
12. Sharma A, Baldi A, Sharma DK. Drug-induced generalized skin eruption in a diabetes mellitus patient receiving a metformin plus simvastatin in a tertiary care teaching hospital in Punjab. Curr Res Diabetes Obes J 2017;4:4-6.
13. Kushawaha SK, Sharma A, Ralta A, Sharma R, Raj D. Pharmacovigilance study : Drugs used in the treatment of tuberculosis at civil hospital rohru (Shimla), Himachal Pradesh. Int J Adv Case Rep 2014;1:37-41.
14. Sharma A, Baldi A, Sharma DK. Drug utilization study at tertiary care hospitals in punjab. Adv Res Gastroentero Hepatol 2017;7(5):101-5.
15. Gastelurrutia P, Benrimoj SI, Espejo J, Tuneu L, Mangues MA, Bayes-Genis A. Negative clinical outcomes associated with drug-related problems in heart failure (HF) outpatients: Impact of a pharmacist in a multidisciplinary HF clinic. J Card Fail 2011;17:217-23.
16. Granas AG, Berg C, Hjellvik V, Haukereid C, Kronstad A, Blix HS, et al. Evaluating categorisation and clinical relevance of drug-related problems in medication reviews. Pharm World Sci 2010;32:394-403.
17. Andreazza RS, Silveira De Castro M, Sippel Köche P, Heineck I. Causes of drug-related problems in the emergency room of a hospital in southern brazil. Gac Sanit 2011;25:501-6.
18. Locke TF, Newcomb MD. Childhood maltreatment, parental alcohol/drugrelated problems, and global parental dysfunction. Prof Psychol Res Pract 2003;34:73-9.
19. Dubova SV, Reyes-Morales H, Torres-Arreola L del P, Suarez-Ortega M. Potential drug-drug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age in family medicine clinics in Mexico City. BMC Health Serv Res 2007;7:147.
20. Westerlund T, Gelin U, Pettersson E, Skärlund F, Wågström K, Ringbom C. A retrospective analysis of drug-related problems documented in a national database. Int J Clin Pharm 2013;35:202-9.
21. Mannheimer B, Ulfvarson J, Eklöf S, Bergqvist M, Andersén-Karlsson E, Pettersson H, et al. Drug-related problems and pharmacotherapeutic advisory intervention at a medicine clinic. Eur J Clin Pharmacol 2006;62:1075-81.
22. Westerlund T, Ttir AB, Melander A. Drug-related problems and pharmacy interventions in community practice. Int J Pharm Pract 1999;7:40-50.
23. Sharma A, Kushawaha SK, Anghore D, Pandit V, Sharma DR. HIV/ AIDS Overview - Recent advancement made by WHO. Adv J Case Rep 2015;6:1582-90.
24. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006;354:731-9.
25. Sharma A, Baldi A, Sharma DK. Drug induced generalized skin eruption in a diabetes mellitus patient receiving a metformin plus simvastatin in a tertiary care teaching hospital in Punjab. Curr Res Diabetes Obes J 2017;4(2):4-6.
26. Cipolle RJ, Pharm D, Strand LM, Morley P. Co-morbidities and drug therapy problems in patients with diabetes. Pharmacologeia 2013;6:144-56.
27. Abraham RR. Drug related problems and reactive pharmacist interventions for inpatients receiving cardiovascular drugs. Int J Basic Med Sci Pharm 2013;3:42-8.
28. Huri HZ, Wee HF. Drug related problems in Type 2 diabetes patients with hypertension: A cross-sectional retrospective study. BMC Endocr Disord 2013;13:2.
29. Neto VC, Garcia VP, Helena ET de S. Possible pharmacological interactions in hypertensive and/or diabetic elderly in family health units at Blumenau (SC). Braz J Pharm Sci 2010;46:795-804.
30. Dinesh KU, Subish P, Pranaya M, Shankar PR, Anil SK, Durga B, et al. Pattern of potential drug-drug interactions in diabetic out-patients in a tertiary care teaching hospital in nepal. Med J Malaysia 2007;62:294-8.
31. Finkers F, Maring JG, Boersma F, Taxis K. A study of medication reviews to identify drug-related problems of polypharmacy patients in the dutch nursing home setting. J Clin Pharm Ther 2007;32:469-76.
32. Meyboom R. Intentional rechallenge and the clinical management of drug-related problems. Drug Saf 2013;36:163-5.
33. Stafford L, Stafford A, Hughes J, Angley M, Bereznicki L, Peterson G. Drug-related problems identified in post-discharge medication reviews for patients taking warfarin. Int J Clin Pharm 2011;33:621-6.
34. Mamgain S, Mathur S, Kothiyal P. Profile of suspect adverse drug reactions in a teaching tertiary care hospital. J Pharmacol Clin Toxicol 2013;1:1-5.
35. Carrasco-Garrido P, Hernández-Barrera V, Esteban-Hernández J, Esteban-Hernández J. Adverse drug reactions to anticoagulants in Spain: Analysis of the Spanish national hospital discharge data (2010-2013). BMJ Open 2017;7:e013224
|
