PHARMASPIRE - Volume 11, Issue 4, October - December, 2019

Pages: 107-111

Date of Publication: 14-Jun-2022

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Development and characterization of hyaluronic acid-loaded ethosomes for topical application

Author: Bharat Khurana, Daisy Arora, Shruti Goswami

Category: Pharmaceutics

Abstract:

Background: Skin aging is such a problem in which actives should be delivered in a deeper layer of skin. Hyaluronic acid (hyaluronan) is a major component of skin, where it is involved in tissue repair. It is also important in maintaining skin firmness and structure. The topical application of hyaluronan helps in maintaining healthy collagen levels and moisturizes the skin. Hyaluronic acid does not easily penetrate the skin when it is applied topically. Methods: Ethosomal formulations were prepared by the “Hot Method.” Optimization of ethosomes was done to get optimal vesicle size. The size, size distribution, and zeta potential of optimized carriers were determined by Zetasizer. An in vitro drug release study of ethosomal formulation was performed phosphate buffer pH 6.8. Results: The ethosomal formulation was found to be optimal for topical use. It was also observed that sodium hyaluronate released from the ethosomes was characterized by a slow release of 25.52 ± 2.08% for 4 h and followed by controlled release. Stability studies indicated that sodium hyaluronate loaded ethosomes are found to be more stable at refrigerated conditions rather than room temperature. Conclusion: Thus, this study described a method for the preparation of ethosomes with lecithin, ethanol, and water, which could be utilized for topical drug delivery successfully.

Keywords: Ethosomes, hyaluronic acid, skin aging, topical delivery

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