PHARMASPIRE - Volume 12, Issue 4, October- December, 2020

Pages: 124-133

Date of Publication: 10-Jun-2022

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Coronavirus disease and its potential therapeutic options: A review

Author: Sharib Raza Khan, Babita Sharma, Prince Singh Rajput, Pooja A. Chawla

Category: Pharmaceutics

Abstract:

Coronavirus disease caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), originated in Wuhan, the city in Hubei territory in China. The virus came out in humans from the Wuhan seafood market by zoonotic transmission. The World Health Organization declared the SARS-CoV-2 outbreak a global pandemic in March 2020. Within few days, the virus had an outreach to many other countries and also across the mainland of China through travelers and somewhat by human-to-human transmission prompting to significant disease burden globally. More than 68.2 million patients have been infected including 1.56 million deaths with this respiratory illness across 210 nations and territories worldwide leading to a global pandemic. As of now, there are no clinically approved vaccines or specific therapeutic drugs available to treat SARS-CoV-2 infections. In this current review, an attempt was made to summarize the information about the description of human coronaviruses, the pathogenesis of respiratory illness at the cellular and molecular level as well as recently available therapeutic medications or treatment options.

Keywords: Severe acute respiratory syndrome coronavirus-2, World Health Organization, global pandemic, human coronaviruses, pathogenesis, treatments

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