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PHARMASPIRE - Volume 13, Issue 3, July - September, 2021

Pages: 91-113

Date of Publication: 07-Jun-2022

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Structural significance of triazole derivatives for the management of various diseases

Author: Arjun Anant, Priti Singh, Vivek Asati

Category: Pharmaceutics


The 1, 2, 4-triazole ring is an important heterocyclic ring having various synthetic uses. Triazole derivatives have been synthesized and published by various researchers as its important characteristic against various diseases. An emphasis has been given to structure–activity relationship, biological activity, and design strategy of various mono as well as polysubstituted triazoles to ensure the acceptance level of this heterocyclic ring in the field of medicinal chemistry. The derivative of this heterocyclic ring produced various biological activities such as anti-inflammatory, anticonvulsant, hypoglycemic, antitubercular, anxiolytic, antimicrobial, antitumor, and anticancer. The current review article focuses of pharmacological profile associated with 1,2,4-triazoles and mainly focuses on structural modification done for various targets along with brief description of targets.

Keywords: 1, 2, 4-triazoles, 1, 3-triazoles, anti-inflammatory, anticonvulsant, hypoglycemic, antitubercular, anxiolytic, antimicrobial, antitumor, and anticancer


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