Pharmaspire


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Pages: 42-53

Date of Publication: 07-Jun-2022

Recent advances in the medicinal chemistry of tetrazole as antibacterial agents: a comprehensive study

Author: Vikrant Rahi , Navneet Kaur , Shubham Kumar, Pinky Arora

Category: Pharmaceutics

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Abstract:

Bacterial infections are rapidly increasing world widely and there is a massive increase in incident of invasive bacterial infections in the past two decades. Development of drug resistance bacteria such as multidrug-resistant strains, intractable pathogens, and newly arising pathogenic organisms is increasing the patients with bacterial infections. Tetrazole hybrids, has a wide range of biological activities, can be used as a privileged scaffold for the development of new lead molecule. Tetrazole moiety can be hybridized with other molecules to develop new molecules with potential antibacterial activity. Various tetrazole based molecules have been designed, synthesized and screened for antibacterial activity in recent years. Some of them are possessing promising activity against various Gram-positive as well as Gram-negative bacteria. Tetrazole has various biological activities such as anticancer, antifungal, antiangiogenic, antiviral, antimalarial, antitubercular, and antibacterial and thus, this has prompted the medicinal chemist to design and develop tetrazole based molecule with the desired biological profile. This review summarizes the recent advances and development in medicinal chemistry of tetrazole hybrids for the development of potential antibacterial agent. This review will provide rationale of various researchers to design more effective tetrazole based clinical candidates.

Keywords: Antibacterial activity, biological activity, molecular docking, tetrazole derivatives

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