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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <ArticleType>P'Ceutical Chemistry</ArticleType>
      <ArticleTitle>Substantiating the mechanism of Boswellic acids via molecular docking study</ArticleTitle>
      <Abstract>Inflammation is the first response shown by the immune system in defense to any attack by bacteria or viruses. Inflammation is responsible for contributing to half of the world’s global burden of disease. It is mainly characterized by pain (dolor), heat (calor), swelling (tumor), and redness (rubor). The inflammatory cascades are the sole reasons for many musculoskeletal disorders. These musculoskeletal disorders are prevalent throughout the world, with a ubiquitous impact leading to long-term pain and disability. They significantly affect the psychosocial status of people who have them. Boswellic acids (BA), a natural mixture isolated from oleo gum resin of Boswellia serrata comprised of four major pentacyclic triterpene acids: beta-boswellic acid, 3-acteyl beta boswellic acid, 11-keto-beta-boswellic acid and 3-acetyl-11-keto-beta-boswellic acid, isolated from the oleo gum resin of Boswellia serrata is reported to be effective as anti-inflammatory, immunomodulatory, anti-tumor, anti-asthmatic and in chronic colitis. Its antiinflammatory activity has been attributed to the inhibition of 5-lipoxygenase in a selective, enzymelinked nonredox and noncompetitive manner. The anti-asthmatic reports on BA revealed that leukotriene and elastase enzyme inhibition might be responsible for this effect. Although BA acts through several mechanisms for its biological activities, but the inhibition of leukotrienes is the primary and the most scientifically proved mechanism. This work substantiates the effect of Boswellia serrata (Boswellic acids) via molecular docking study into the cavity of 5-LOX enzyme.</Abstract>
      <Keywords>5-LOX, Antiinflammatory, Boswellic acid, Boswellia serrata</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=14174&amp;title=Substantiating the mechanism of Boswellic acids via molecular docking study</Abstract>