<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <Volume-Issue>Volume 11, Issue 1</Volume-Issue>
      <Season>January-March, 2019</Season>
      <ArticleTitle>Design, synthesis, and evaluation of pyrimidine bridged chalcone derivatives of naphthalene as antibacterial agents</ArticleTitle>
      <Abstract>Pyrimidines, due to their very distinct and unique place in our lives, have provoked significant interest of medicinal chemists in the development of novel antibacterial agents. Thus, with the aim to discover new potentially active antibacterial agents, we have synthesized some new pyrimidine bridged chalcone derivatives of naphthalene and investigated their antimicrobial activities against pathogenic microbial strains, Bacillus subtilis (MTCC 2451), Pseudomonas aeruginosa (MTCC 2642), and Escherichia coli (MTCC 82) by disk diffusion method. The compounds were found to possess moderate activity against all tested strains. In general, the new synthesized compounds showed a good antimicrobial activity against these microorganisms.</Abstract>
      <Keywords>Antibacterial, pyrimidine derivatives, chalcone, naphthalene derivatives</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13871&amp;title=Design, synthesis, and evaluation of pyrimidine bridged chalcone derivatives of naphthalene as antibacterial agents</Abstract>
        <References>1. Chopra I, Schofield C, Everett M, O’Neill A, Miller K, Wilcox M, et al. Treatment of health-care-associated infections caused by gram-negative bacteria: A consensus statement. Lancet Infect Dis 2008;8:133-9.&#13;
2. Taylor PW, Stapleton PD, Luzio JP. New ways to treat bacterial infections. Drug Discov Today 2002;7:1086-91. &#13;
3. Sharma V, Chitranshi N, Agarwal AK. Significance and biological importance of pyrimidine in the microbial world. Int J Med Chem 2014;2014:202784. &#13;
4. Khalifa NM, Adel AH, Abd-Elmoez SI, Fathalla OA, El-Gwaad AA. A convenient synthesis of some new fused pyridine and pyrimidine derivatives of antimicrobial profiles. Res Chem Intermed 2015;41:2295-305.&#13;
5. Pilch DS, Levenson C, Shafer RH. Structure, stability, and thermodynamics of a short intermolecular purine-purine-pyrimidine triple helix. Biochemistry 1991;30:6081-7.&#13;
6. Holla BS, Mahalinga M, Karthikeyan MS, Akberali PM, Shetty NS. Synthesis of some novel pyrazolo [3, 4-d] pyrimidine derivatives as potential antimicrobial agents. Bioorganic Med Chem 2006;14:2040-7.&#13;
7. Mohamed MS, Awad SM, Sayed AI. Synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents. Molecules 2010;15:1882-90. &#13;
8. Ahmed O, Hussein A, Ahmed R. Antidiabetic and antioxidant effects of newly synthesized pyrimido [1, 6-a] pyrimidine derivatives in neonatal streptozotocin-induced diabetic rats. Med Chem 2012;2:20-8. &#13;
9. Barakat A, Soliman SM, Al-Majid AM, Lotfy G, Ghabbour HA, Fun H, et al. Synthesis and structure investigation of novel pyrimidine-2, 4, 6-trione derivatives of highly potential biological activity as anti-diabetic agent. J Mol Struct 2015;1098:365-76. &#13;
10. Hilmy KM, Khalifa MM, Hawata MA, Keshk RM, El-Torgman AA. Synthesis of new pyrrolo [2, 3-d] pyrimidine derivatives as antibacterial and antifungal agents. Eur J Med Chem 2010;45:5243-50.&#13;
11. Maddila S, Gorle S, Seshadri N, Lavanya P, Jonnalagadda SB. Synthesis, antibacterial and antifungal activity of novel benzothiazole pyrimidine derivatives. Arab J Chem 2016;9:681-7. &#13;
12. Patle S, Kawathekar N, Zaveri M, Kamaria P. Synthesis and evaluation of 2, 4, 6-trisubstituted pyrimidine derivatives as novel antileishmanial agents. Med Chem Res 2013;22:1756-61. &#13;
13. Suryawanshi S, Kumar S, Shivahare R, Pandey S, Tiwari A, Gupta S. Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents. Bioorg Med Chem Lett 2013;23:5235-8. &#13;
14. Amir M, Javed S, Kumar H. Pyrimidine as antiinflammatory agent: A review. Indian J Pharm Sci 2007;69:337.&#13;
15. Amr AE, Sayed HH, Abdulla MM. Synthesis and reactions of some new substituted pyridine and pyrimidine derivatives as analgesic, anticonvulsant and antiparkinsonian agents. Arch Pharm 2005;338:433-40. &#13;
16. Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, et al. Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4- aryl-1, 4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents. J Med Chem 1992;35:3254-63. &#13;
17. Nasr MN, Gineinah MM. Pyrido [2, 3-d] pyrimidines and pyrimido [5’, 4’: 5, 6] pyrido [2, 3-d] pyrimidines as new antiviral agents: Synthesis and biological activity. Arch Pharm 2002;335:289-95.&#13;
18. Guan LP, Sui X, Chang Y, Yan ZS, Tong GZ, Qu YL. Design, synthesis and anticonvulsant activity evaluation of 7-substituted-[1, 2, 4]-triazolo [4, 3-f] pyrimidine derivatives. Med Chem 2012;8:1076-83.&#13;
19. Abu-Hashem A, El-Shehry M, Badria F. Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents. Acta Pharm 2010;60:311-23.&#13;
20. Rostom SA, Ashour HM, Razik HA. Synthesis and biological evaluation of some novel polysubstituted pyrimidine derivatives as potential antimicrobial and anticancer agents. Arch Pharm 2009;342:299-310.&#13;
21. Lukasik PM, Elabar S, Lam F, Shao H, Liu X, Abbas AY, et al. Synthesis and biological evaluation of imidazo [4, 5-b] pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents. Eur J Med Chem 2012;57:311-22. &#13;
22. Kumar B, Sharma P, Gupta VP, Khullar M, Singh S, Dogra N, et al. Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies. Bioorg Chem 2018;78:130-40. &#13;
23. Kumar B, Kumar M, Dwivedi AR, Kumar V. Synthesis, biological evaluation and molecular modeling studies of propargyl-containing 2, 4, 6-trisubstituted pyrimidine derivatives as potential anti-parkinson agents. Chem Med Chem 2018;13:705-12.&#13;
24. Kumar B, Kumar V, Prashar V, Saini S, Dwivedi AR, Bajaj B, et al. Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase. Eur J Med Chem 2019;177:221-34. &#13;
25. Kumar B, Dwivedi AR, Sarkar B, Gupta SK, Krishnamurthy S, Mantha AK, et al. 4, 6-diphenylpyrimidine derivatives as dual inhibitors of monoamine oxidase and acetylcholinesterase for the treatment of Alzheimer’s disease. ACS Chem Neurosci 2018;10:252-65. &#13;
26. Mondal P, Jana S, Kanthal LK. Synthesis of novel mercapto-pyrimidine and amino-pyrimidine derivatives of indoline-2-one as potential antioxidant and antibacterial agent. Pharma Res 2010;3:17-26. &#13;
27. Solankee A, Lad S, Solankee S, Patel G. Chalcones, pyrazolines andaminopyrimidines as antibacterial agents. Ind J Chem 2009;48:1442-46.&#13;
28. Bansod S, Rai M. Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World J Med Sci 2008;3:81-8.</References>