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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <Volume-Issue>Volume 13, Issue 3</Volume-Issue>
      <Season>July - September, 2021</Season>
      <ArticleTitle>Design, synthesis, and antibacterial evaluation of arylidene derivatives of rhodanine-3-hexanoic acid</ArticleTitle>
          <FirstName>Abhishek Kumar</FirstName>
      <Abstract>Background: Due to the development of resistance to various traditional antibacterial medications, bacterial infections represents a significant problem for healthcare professionals. Thus, there are unsatisfactory medical requirements for new bacteria and bacterial infections.&#13;
Rationale: Rhodanine derivatives substituted with carboxyalkyl acid moiety have been reported to possess potent antimicrobial activity through a novel mechanism. However, their antibacterial potential has not been completely explored.&#13;
Results: Therefore, in the present study, series of rhodanine-3-hexanoic acid derivatives bearing hydroxyl substituted benzylidene moiety at the C-5 position of the rhodanine core were synthesized through Knoevenagel condensation of rhodanine-3-hexanoic acid with various hydroxyl substituted aromatic aldehydes. All the compounds were structurally characterized and evaluated in vitro for their antibacterial activity against two Gram-positive and two Gram-negative bacterial strains.&#13;
Conclusion: Biological data showed that synthesized derivatives exhibited potent to moderate antibacterial activity against the tested bacterial strains. The lead identified in the present study can be further explored for the design of potent antimicrobial agents.</Abstract>
      <Keywords>2-thiazolidine-4-one, antibacterial activity, antimicrobial activity, rhodanine</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13783&amp;title=Design, synthesis, and antibacterial evaluation of arylidene derivatives of rhodanine-3-hexanoic acid</Abstract>
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