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      <Volume-Issue>Volume 13, Issue 4 </Volume-Issue>
      <Season>October - December, 2021</Season>
      <ArticleTitle>Pharmacological development of the animal model of streptozotocin-induced memory dysfunction in adult Zebrafish</ArticleTitle>
      <Abstract>Hyperglycemia affects the central nervous system and its functions including learning and memory. Streptozotocin (STZ) in hyperglycemic condition leads to the production of reactive oxygen species and reduce the level of nitric oxide, and crucial factor for vascular endothelial dysfunction which causes memory impairment. Adult zebrafish (approximately 3 months old, 470–530 mg) were subjected to the STZ administration (50, 100, 200, 300, 400, 500, 600 mg/kg). The animals were divided into two groups – control and test group. STZ administration causes significant changes in blood glucose level, behavioral and biochemical parameters at the dose of STZ 300 mg/kg. With an increasing dose of STZ there was significant (P &lt; 0.0001) rise in blood glucose level. In light and dark chamber test, STZ (300 mg/kg) causes significant (P &lt; 0.0001) change by showing their preference in the dark compartment and increase in the number of entries in the dark compartment as compared to the normal group which is the indicator of spatial memory loss. In the T-maze test STZ treated groups (300 mg/kg and above) have shown a significant (P &lt; 0.0001) (decrease in time spent in the favorable zone and transfer latency to enter into the favorable zone which indicates the cognitive decline in the zebrafish with a significant (P &lt; 0.0001) rise in blood glucose level. Moreover, STZ (300 mg/kg) causes significant (P &lt; 0.0001) enhancement in brain lipid peroxidation and AChEs activity. In this study, we have observed that STZ at the dose of 300 mg/kg is sufficient in producing memory impairment in adult zebrafish.</Abstract>
      <Keywords>Cognitive impairment, streptozotocin, zebrafish, T-maze, acetylcholinestrase activity, oxidative stress, light and dark test</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13772&amp;title=Pharmacological development of the animal model of streptozotocin-induced memory dysfunction in adult Zebrafish</Abstract>
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