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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <Volume-Issue>Volume 13, Issue 4 </Volume-Issue>
      <Season>October - December, 2021</Season>
      <ArticleTitle>Design, synthesis and evaluation of some newly synthesized Pyranoquinolinone derivatives as potential antimicrobial agents</ArticleTitle>
          <FirstName>Preet Mohinder Singh</FirstName>
          <FirstName>Kanaya Lal</FirstName>
      <Abstract>A mild and efficient method for the synthesis of (JCMQ-1-24) through a twocomponent reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone (JC-1) and intermediate arylidenes (JCM-1-24) catalyzed by piperidine is described. This new procedure has the advantages of mild reaction condition, high yields, and metal-free catalyst. A library of 22 pyranoquinolinone derivatives, with substituents at positions 2, 3, 4, and 5 were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depends on the substituents attached to the pyran ring.</Abstract>
      <Keywords>Aromatase, 4-Hydroxy-1-methyl-2(1H)-quinolinone, knoevenagel condensation, pyranoquinolinones, antimicrobial activity</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13771&amp;title=Design, synthesis and evaluation of some newly synthesized Pyranoquinolinone derivatives as potential antimicrobial agents</Abstract>
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