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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
      <Volume-Issue>Volume 13, Issue 4 </Volume-Issue>
      <Season>October - December, 2021</Season>
      <ArticleTitle>Design, synthesis, and characterization of new thiazolidinedione derivatives as potent __ampersandsignalpha;-glucosidase inhibitors</ArticleTitle>
      <Abstract>In an effort to find new antidiabetic agents, we carried out the design and synthesis of new thiazolidinedione derivatives and evaluated them as __ampersandsignalpha;-glucosidase inhibitors. All the synthesized derivatives were evaluated for __ampersandsignalpha;-glucosidase inhibitory activity. All the derivatives showed good inhibitory potential against __ampersandsignalpha;-glucosidase with IC50 values ranging between 35.74 ---PlusMinusSymbol--- 0.134 and 12.29 ---PlusMinusSymbol--- 1.86 __ampersandsignmu;g/mL. Among all the synthesized derivatives, 12d emerged to be the most potential inhibitor of __ampersandsignalpha;-glucosidase bearing IC50 value of 12.29 ---PlusMinusSymbol--- 1.86 __ampersandsignmu;g/mL. Owing to the results, it can be concluded that the lead identified in the present study can be further explored for the design of potent __ampersandsignalpha;-glucosidase inhibitors as antidiabetic agents.</Abstract>
      <Keywords>Thiazolidinedione, ?-glucosidase inhibitors, antidiabetic agents, synthesis, in vitro studies</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13767&amp;title=Design, synthesis, and characterization of new thiazolidinedione derivatives as potent __ampersandsignalpha;-glucosidase inhibitors</Abstract>
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