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      <Volume-Issue>Volume 13, Issue 4 </Volume-Issue>
      <Season>October - December, 2021</Season>
      <ArticleTitle>Synthesis and antibacterial evaluation of naphthalene based 1,5-benzodiazepine derivatives</ArticleTitle>
      <Abstract>Various substituted 1,5-benzodiazepines were synthesized by condensing different naphthalene-based chalcones with o-phenylenediamine in methanol using piperidine as a base under refluxing conditions and were obtained in good yield after purification. The final compounds (5a-e) were structurally elucidated and evaluated in vitro for antibacterial activity against three human pathogenic bacterial strains using the disc diffusion method and MIC was determined by serial dilution method. The antibacterial evaluation led to the identification of compounds 5d and 5e as the most potent molecule of the series. The promising compounds identified in the study can be exploited in near future for the design of more potent candidates with better efficacy.</Abstract>
      <Keywords>1,5-Benzodiazepines, antibacterial activity, chalcones, naphthalene</Keywords>
        <Abstract>https://isfcppharmaspire.com/ubijournal-v1copy/journals/abstract.php?article_id=13765&amp;title=Synthesis and antibacterial evaluation of naphthalene based 1,5-benzodiazepine derivatives</Abstract>
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