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PHARMASPIRE - Volume 15, Issue 03, 2023 , July- September

Pages: 184-188

Date of Publication: 11-Dec-2023

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Questioners for assessing quality of life in people with epilepsy

Author: Hardik Kumar, Amit Sharma

Category: Pharmacy Practice


It is generally accepted that health-related quality of life (HRQOL) refers to “an evaluation of one’s wellbeing based on consideration of physical, mental, social, and general health status.” In this review, we provide information from current studies on the main and most used QOL measures for both adults and children with epilepsy. Measurement of HRQOL aims at capturing such patient centered effects of therapy. Different epilepsy-specific instruments such as QOLIE-89, quality of life in epilepsy inventory (QOLIE-31), QOLIE-10, quality of life in epilepsy inventory for adolescent (QOLIE-AD48), epilepsy surgery inventory (ESI55), side effects and life satisfaction, Liverpool HRQOL Battery, and Washington psychosocial seizure inventory (WPSI) are used to determine QOL. This concludes that there were instruments that should be preferred for future use. The WPSI will be used for the mental and social measures, ESI-55 for surgery, QOL in Epilepsy QOLIE-31 used for adults, Liverpool QOL Batteries used for frequency and intensity of seizure, and QOLIE-AD-48 used for adults.

Keywords: Epilepsy, Health-related quality of life, Quality of life, Seizure

DOI: 10.56933/Pharmaspire.2023.15129



1. Vellone E, Piras G, Talucci C, Cohen MZ. Quality of life for caregivers of people with Alzheimer’s disease. J Adv Nurs 2008;61:222-31.

2. Gasper D. Understanding the diversity of conceptions of well-being and quality of life. J Soc Econ 2010;39:351-60.

3. Weight CJ, Sellon JL, Lessard-Anderson CR, Shanafelt TD, Olsen KD, Laskowski ER. Physical activity, quality of life, and burnout among physician trainees: The effect of a team-based, incentivized exercise program. Mayo Clin Proc 2013;88:1435-42.

4. Hays RD, Anderson R, Revicki D. Psychometric considerations in evaluating health-related quality of life measures. Qual life Res 1993:441-9.

5. Lindström B. Quality of life: A model for evaluating health for all. Conceptual considerations and policy implications. Soz Praventivmed 1992;37:301-6.

6. Boswell BB, Dawson M, Heininger E. Quality of life as defined by adults with spinal cord injuries. J Rehabil 1998;64:27-33.

7. Jacoby A, Baker GA, Crossley J, Schachter S. Tools for assessing quality of life in epilepsy patients. Expert Rev Neurother 2013;13:1355-69.

8. Cramer JA, Smith DB, Mattson RH, Delgado Escueta AV, Collins JF. A method of quantification for the evaluation of antiepileptic drug therapy. Neurology 1983;3 Suppl 133:26-37.

9. Baker GA, Smith DF, Dewey M, Jacoby A, Chadwick DW. The initial development of a health-related quality of life model as an outcome measure in epilepsy. Epilepsy Res 1993;16:65-81.

10. O’Donoghue MF, Duncan JS, Sander JW. The national hospital seizure severity scale: A further development of the chalfont seizure severity scale. Epilepsia 1996;37:563-71.

11. Paradiso B, Marconi P, Zucchini S, Berto E, Binaschi A, Bozac A, et al. Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. Proc Natl Acad Sci U S A 2009;106:7191-6.

12. Wagner AK, Keller SD, Kosinski M, Baker GA, Jacoby A, Hsu MA, et al. Advances in methods for assessing the impact of epilepsy and antiepileptic drug therapy on patients’ health-related quality of life. Qual Life Res 1995;4:115-34.

13. Wright GD, McLellan DL, Brice JG. A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy. J Neurol Neurosurg Psychiatry 1984;47:769-74.

14. Abetz L, Jacoby A, Baker GA, McNulty P. Patientbased assessments of quality of life in newly diagnosed epilepsy patients: Validation of the NEWQOL. Epilepsia 2000;41:1119-28.

15. Lennox WG, Lennox MA. Epilepsy and Related Disorders. Vol. 1. Boston: Little, Brown; 1960. p. 454-5.

16. Taylor DC. The components of sickness: Diseases, illnesses, and predicaments. Lancet 1979;2:1008-10.

17. Dodrill CB, Batzel LW, Queisser HR, Temkin NR. An objective method for the assessment of psychological and social problems among epileptics. Epilepsia 1980;21:123-35.

18. Dodrill CB, Arnett JL, Sommerville KW, Sussman NM. Evaluation of the effects of vigabatrin on cognitive abilities and quality of life in epilepsy. Neurology 1993;43:2501-7.

19. Chang CH, Gehlert S. The Washington psychosocial seizure inventory (WPSI): Psychometric evaluation and future applications. Seizure 2003;12:261-7.

20. Cramer JA. Quality of life for people with epilepsy. Neurol Clin 1994;12:1-13.

21. Trostle JA, Hauser WA, Sharbrough FW. Psychologic and social adjustment to epilepsy in Rochester, Minnesota. Neurology 1989;39:633-7.

22. Wiebe S, Rose K, Derry P, McLachlan R. Outcome assessment in epilepsy: Comparative responsiveness of quality of life and psychosocial instruments. Epilepsia 1997;38:430-8.

23. Kendrick AM, Trimble MT. Repertory grid in the assessment of quality of life in patients with epilepsy: The quality of life assessment schedule. Epilepsy Qual life1999;4:151-64.

24. Wiebe S, Derry PA. Measuring quality of life in epilepsy surgery patients. Can J Neurol Sci 2000;27 Suppl 1:S111-5.

25. Vickrey BG, Hays RD, Graber J, Rausch R, Engel J Jr., Brook RH. A health-related quality of life instrument for patients evaluated for epilepsy surgery. Med Care 1992;30:299-319.

26. Bergner M, Bobbitt RA, Carter WB, Gilson BS. The sickness impact profile: Development and final revision of a health status measure. Med Care 1981;19:787-805.

27. Vickrey BG, Hays RD, Engel J Jr., Spritzer K, Rogers WH, Rausch R, et al. Outcome assessment for epilepsy surgery: The impact of measuring health-related quality of life. Ann Neurol 1995;37:158-66.

28. Hauer J, Houtrow AJ, Section on Hospice and Palliative Medicine, Council on Children with Disabilities. Pain assessment and treatment in children with significant impairment of the central nervous system. Pediatrics 2017;139:e20171002.

29. Send SR. The Impact of a Low-Carbohydrate, High-Fat Modified Ketogenic Diet on Seizure Severity, Seizure Frequency, and Quality of Life in Adult Patients with Epilepsy. Chicago: Rush University; 2016.

30. Mollao?lu M, Durna Z, Bolayir E. Validity and reliability of the quality of life in epilepsy inventory (QOLIE-31) for Turkey. Noro Psikiyatr Ars 2015;52:289-95.

31. Andrade-Machado R, Ochoa-Urrea M, Garcia-Espinosa A, Benjumea-Cuartas V, Santos-Santos A. Suicidal risk, affective dysphoric disorders, and quality-of-life perception in patients with focal refractory epilepsy. Epilepsy Behav 2015;45:254-60.

32. LaRocca NG, Ritvo PG, Miller DM, Fischer JS, Andrews H, Paty DW. Quality of life assessment in multiple sclerosis clinical trials: Current status and strategies for improving multiple sclerosis clinical trial design. In: Multiple Sclerosis: Advances in Clinical Trial Design, Treatment and Future Perspectives. Germany: Springer; 1996. P. 145-160.

33. Monteiro Ede A, Osório Fde L, Veriano A Jr., Molina RS, Funayama SS, Terra VC, et al. Validation of the subjective handicap of epilepsy (SHE) in Brazilian patients with epilepsy. Epilepsy Behav 2012;24:345-51.