Join us   Log in  

PHARMASPIRE - Volume 11, Issue 1, January-March, 2019

Pages: 29-33

Date of Publication: 14-Jun-2022

Print Article   Download XML  Download PDF

Development and evaluation of pulsatile drug delivery system of pantoprazole sodium for the management of nocturnal acid breakthrough

Author: Daisy Arora, Bharat Khurana, Sukhbir Kaur

Category: Pharmaceutics


Background: The aim of the present investigation was to develop a pulsatile drug delivery system of pantoprazole sodium for the management of peptic ulcer (PU) due to nocturnal acid breakthrough. PU disease is a group of disorders characterized by the presence of ulcers in any portion of the gastrointestinal tract exposed to acid in sufficient concentration and duration. Press-coated tablets were prepared by first preparing the inner core tablets using the direct compression method and then recompressing the core tablet with the coating layer. The type and concentration of disintegrant in the core tablet were varied in different formulations to optimize the best tablets in terms of immediate release and quick disintegration. Methods: Press-coated tablets were prepared with varying concentration of coating material, i.e., hydroxypropyl methylcellulose (HPMC) K4 M and ethyl cellulose to optimize the lag time. Results: The blend of HPMC and ethyl cellulose in a ratio of 40:60 showed the desired lag time of approximately 3 h and then burst immediate release with the highest dissolution rate as compared to other ratios. Conclusion: The chrono delivery of pantoprazole sodium could be achieved by formulating the tablet by compression or press-coating technique.

Keywords: Pantoprazole sodium, peptic ulcer, pulsatile drug delivery, press-coated tablets; dissolution


1. Khurana B, Arora D, Narang R. Topical delivery of nanoemulsion for antipsoriatic drugs. J Drug Deliv Ther 2018;8:1-11.

2. Kaur A, Singh R, Sharma R, Sunil K. Peptic ulcer: A review on etiology and pathogenesis. Int Res J Pharm 2012;3:34-8.

3. Rao NG, Soumya P, Revathi K, Nayak BS. A review on pulsatile drug delivery system. Int Res J Pharm 2013;4:31-44.

4. Khurana B, Goyal AK, Budhiraja A, Aora D, Vyas SP. Lipoplexes versus nanoparticles: PDNA/siRNA delivery. Drug Deliv 2013;20:57-64.

5. Singh A, Dubey H, Shukla I, Singh DP. Pulsatile drug delivery system: An approach of medication according to circadian rhythm. J Appl Pharm Sci 2012;2:166-76.

6. Prasanth VV, Modi MP, Mathew ST, Abraham A. Formulation and evaluation of enteric coated time release press coated tablets of theophylline for chronopharmacotherapy. Pharm Lett 2012;4:599-606.

7. Tuorkey MJ, Abdul-aziz KK. Gastric ulcer’s diseases pathogenesis, complications and strategies for prevention. Webmedcentral Gastroenterol 2011;2:1-24.

8. Arora D, Khurana B, Narang RK, Nanda S. Quality by design (QbD) approach for optimization and development of nano drug delivery systems. Trends Drug Deliv 2016;3:23-32.

9. Khadabadi SS, Chishti NH, Khan FM, Tadvee AA. Formulation and evaluation of press coated tablet of ketoprofen-a chronotherapeutic approach. Int J Pharm Pharm Sci 2013;5:733-40.

10. Domala R, Eedara BB, Dhurke RK. Development of pulsatile drug delivery system using novel solubilizers for antihypertensive drug. Int J Pharm Pharm Sci 2014;6:659-64.

11. Kamalakkannan V, Kannan C, Jaganathan K, Kumaran KS, Kumar RS. Formulation and in vitro evaluation of aceclofenac pulsatile tablets as a oraltime controlled drug delivery system. Arch Appl Sci Res 2013;5:121-31.

12. Arora D, Nanda S. Quality by design driven development of resveratrol loaded ethosomal hydrogel for improved dermatological benefits via enhanced skin permeation and retention. Int J Pharm 2019;567:118448.

13. Arya RK, Juyal V, Singh R. Development and evaluation of gastroresistant microspheres of pantoprazole. Int J Pharm Pharm Sci 2010;2:112-6.

14. Mogal RT, Galgatte UC, Chaudhari PD. Floating pulsatile drug delivery of ranitidine hydrochloride for nocturnal acid breakthrough: Design, optimization, in vitro and in vivo evaluation. Int J Pharm Pharm Sci 2013;5:722-7.

15. Pahwa R, Kumar V, Kohli K. Clinical manifestations, causes and management strategies of peptic ulcer disease. Int J Pharm Sci Drug Res 2010;2:99-106.

16. Pahal S, Arora D, Kumar MS, Mahadevan N. Development of paclitaxel loaded immunonanoparticles for HER-2 positive breast cancer cells. Int J Recent Adv Pharm Res 2011;1:25-39.

17. Arora D, Khurana B, Kumar MS, Vyas SP. Oral immunization against hepatitis B virus using. Int J Recent Adv Pharm Res 2011;1:45-51.

18. Sirisha VN, Namrata M, Sruthi B, Harika I, Kirankumar P, Kiran Y, et al. Pulsatile drug delivery system-a review. Int J Pharm Res Allied Sci 2012;1:13-23.