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PHARMASPIRE - Volume 10, Issue 1, January-March, 2018

Pages: 29-40

Date of Publication: 14-Jun-2022

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Release kinetic study of enteric coating of senna tablet

Author: Ramchander Khatri , Tanuj Hooda , Rakesh Gupta , Prashant Kumar , Pawan Jawal

Category: Pharmaceutics


The development of enteric coated formulation has been one approach to preventing the drug from coming into contact with gastric mucosa. The enteric coating dosage form releases the drug after leaving the stomach. The results of this study indicate that enteric coated tablets using 12% cellulose acetate phthalate (CAP) are suitable for the senna drug which is mainly active in the lower Gastrointestinal track. The physical compatibility study at 40°C/75% RH showed that senna extract, ajowan oil, and excipients used during the research work found to be physically compatible. The tablet formulation was prepared by wet granulation technique, and the physical characteristics of granules were evaluated for moisture content (%), compressibility index, angle of repose, Hausner ratio and found to have good flow and compressibility. The tablet formulations developed were found to be within the limits with respect to in-process parameters such as thickness, hardness, friability, weight variation, and disintegration time. The different trail batches of enteric coated tablets were developed using a different percentage of CAP, and drug release profile of different batches were studies with the help of five kinetic models, namely zero order, first order, Higuchi, Hixon-crowell, and Korsmeyer-Peppas model. The entire kinetic models studied for all the batches of different concentration of CAP. The batch containing 4% CAP, it was observed that the batch followed zero-order kinetic model because of having maximum R2 value of 0.990. The batch having 8% CAP and it was observed that the batch followed zero-order kinetic model because of having maximum R2 value of 0.959. The batch having 12% CAP and it was observed that the batch followed Higuchi model because of having maximum R2 value of 0.999. The batch having 16% CAP and it was observed that the batch followed Hixon-Crowell model and Higuchi model both because of having maximum R2 value of 0.991. The batch having 20% CAP, it was observed that the batch followed zero-order kinetic and Higuchi kinetic model because of having maximum R2 value of 0.984. The batch having 24% CAP, it was observed that the batch followed Hixon-Crowell kinetic model because of having maximum R2 value of 0.981.

Keywords: Senna, tablet, cellulose acetate phthalate, pharmacokinetic


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