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PHARMASPIRE - Volume 10, Issue 1, January-March, 2018

Pages: 01-06

Date of Publication: 14-Jun-2022

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DNA technology as potential tool for neurological disorders

Author: Sharma Vaishali , Awasthi Anupam

Category: Pharmaceutics


Spontaneous decay or rupture of DNA caused by many of the factors leads to DNA damage such as mutation, single-strand breaks, double-strand breaks, mismatching, deamination, hydrolysis, and oxidation. DNA can be repaired by base excision repair, NER, direct excision, recombination, etc. This technique helps to treat many of the genetic disorders naturally or in the laboratories such as aging, carcinogenesis, diabetes, teratogenic complications, and cardiomyopathy. Various techniques were used such as polymerase chain reaction, different blottings, and gel electrophoresis. The future of the medical science on the basis of DNA repair to treat many neurological disorders will appear as a blockbuster in the upcoming few years. In the present paper authors have summarized various techniques to identify DNA damage, DNA repair and various applications of these techniques in treatment of different types of neurological disorders such as Huntington’s disease, Alzheimer’s disease and schizophrenia etc.

Keywords: Double-strand breaks, electrophoresis, polymerase chain reaction, single-strand breaks, teratogenicity


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