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PHARMASPIRE - Volume 13, Issue 1, January-March 2021

Pages: 21-27

Date of Publication: 09-Jun-2022

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In vitro anti-inflammatory and antioxidant activity of Nephrolepis cordifolia and molecular docking of its active chemical constituent

Author: Rohit Pal, Ghanshyam Teli, Bharti Sharma, Bhupinder Kumar, Pooja A Chawla

Category: Pharmaceutics


Nephrolepis cordifolia is a fern native to northern Australia and Asia. It has many common names including fishbone fern, tuberous sword fern, tuber ladder fern, erect sword fern, narrow sword fern and ladder fern, and herringbone fern. N. cordifolia is a wood fern that typically grows in woodland areas. Both fertile and sterile fronds are pinnate, up to 3 feet in length and 3 inches wide. There are many leaflets, or pinnae, ranging from 40 to 100 mm (1.5 to 4 inches) on each side of the rachis. Each pinna is oblong to lanceolate with an auricle that overlaps rachis. Rhizomes are orange/brown to pale brown with linear scales having hair like tips. Stolon is straw colored and produces small underground tubers. The presence of tubers distinguishes sword fern from the native N. cordifolia fern. The aim of the present study was to evaluate the antioxidant and antiinflammatory activity of ethanolic extract of leaves of N. cordifolia. The active chemical constituents were docked to establish the possible mechanism of action.

Keywords: Anti-inflammatory, antioxidant, ethanolic extract, fern, Nephrolepis cordifolia


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