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PHARMASPIRE - Volume 13, Issue 1, January-March 2021

Pages: 01-07

Date of Publication: 09-Jun-2022


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Exploring the role of chalcones to treat microbial infections: A mini-review

Author: Bharti Sharma, Pooja A. Chawla

Category: Pharmaceutics

Abstract:

Chalcones, also known as α, β-unsaturated ketones, are present in some natural products as a major constituent. Chalcones and their derivatives are biologically active molecules that have been an area of great interest from a medicinal view of point in current years. Synthetic manipulations of chalcones or their isolation from natural sources are being looked over worldwide for the expansion of more potent and effective drugs for the treatment of several dreadful diseases including cancer, diabetes, HIV, tuberculosis, and malaria. In previous years, a large volume of research papers and review articles highlighting the biological activity of chalcone derivatives has been compiled in the literature. Chalcones possessed a wide array of biological activity. Few of these biological activities include anti-cancer, anti-aggregation, anti-microbial, and so on. In this review, we have discussed chalcones as antimicrobial agents and also we have highlighted a detailed structure-activity relationship study along with in vitro activity

Keywords: Anti-microbial activity, chalcones, Claisen-Schmidt condensation, structure-activity relationship

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