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PHARMASPIRE - Volume 13, Issue 2, April - June, 2021

Pages: 54-63

Date of Publication: 07-Jun-2022


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Recent updates on extraction techniques of bioactive compounds

Author: Priti Singh , Arjun Anant, Abhishek Pathak , Vivek Asati

Category: Pharmaceutics

Abstract:

Bioactive compounds obtained from different natural resources and showed valuable effects in the treatment of various diseases. Extraction processes for these compounds depend on various factors such as the organic solvent, technique that is used, and the raw material. This review focuses on the extraction of bioactive compounds from food by-products of plant origin by a number of novel methods. The various extraction techniques and their recent updates have been summarized to reduce the economic and ecological impact of these processes. In the present review, we tried to explore some novel things related to these techniques with their schematic presentation, which may be helpful for the researchers for selecting right path for extraction of bioactive compounds.

Keywords: Extraction methods, bioactive compounds, soxhlet extraction, ultrasonic extraction, enzyme-assisted extraction

References:

1. Maqsood S, Adiamo O, Ahmad M, Mudgil P. Bioactive compounds from date fruit and seed as potential nutraceutical and functional food ingredients. Food Chem 2020;308:125522.

2. Patil L, Kaliwal BB. Microalga Scenedesmus bajacalifornicus BBKLP-07, a new source of bioactive compounds with in vitro pharmacological applications. Bioproc Biosyst Eng 2019;42:979-94.

3. Lyte M. Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. Bioessays 2011;33:574-81.

4. de Morais MG, Vaz BD, de Morais EG, Costa JA. Biologically active metabolites synthesized by microalgae. BioMed Res Int 2015;2015:835761.

5. Gouda S, Das G, Sen SK, Shin HS, Patra JK. Endophytes: A treasure house of bioactive compounds of medicinal importance. Front Microbiol 2016;7:1538.

6. da Silva PM, Gauche C, Gonzaga LV, Costa AC, Fett R. Honey: Chemical composition, stability and authenticity. Food Chem 2016;196:309-23.

7. Tesfaye T. Valorisation of mango fruit by-products: Physicochemical characterization and future prospect. Chem Proc Eng Res 2017;50:22-34.

8. Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA. Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts. Plants 2017;6:42.

9. Alvin A, Miller KI, Neilan BA. Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds. Microbiol Res 2014;169:483-95.

10. Zia S, Khan MR, Shabbir MA, Aslam Maan A, Khan MK, Nadeem M, et al. An inclusive overview of advanced thermal and non-thermal extraction techniques for bioactive compounds in food and food-related matrices. Food Rev Int 2020;2020:1-31.

11. Dominguez H, Muñoz MJ, editors. Water Extraction of Bioactive Compounds: From Plants to Drug Development. Netherlands: Elsevier; 2017.

12. Chuo SC, Nasir HM, Mohd-Setapar SH, Mohamed SF, Ahmad A, Wani WA, et al. A glimpse into the extraction methods of active compounds from plants. Crit Rev Anal Chem 2020;2020:1-30.

13. Cunha SC, Fernandes JO. Extraction techniques with deep eutectic solvents. TrAC Trends Anal Chem 2018;105:225-39.

14. Roselló-Soto E, Koubaa M, Moubarik A, Lopes RP, Saraiva JA, Boussetta N, et al. Emerging opportunities for the effective valorization of wastes and by-products generated during olive oil production process: Non-conventional methods for the recovery of high-added value compounds. Trends Food Sci Technol 2015;45:296-310.

15. Filly A, Fernandez X, Minuti M, Visinoni F, Cravotto G, Chemat F. Solvent-free microwave extraction of essential oil from aromatic herbs: From laboratory to pilot and industrial scale. Food Chem 2014;150:193-8.

16. Berton P, Lana NB, Ríos JM, García-Reyes JF, Altamirano JC. State of the art of environmentally friendly sample preparation approaches for determination of PBDEs and metabolites in environmental and biological samples: A critical review. Anal Chim Acta 2016;905:24-41.

17. Lee NY, Yunus MA, Idham Z, Ruslan MS, Aziz AH, Irwansyah N. Extraction and identification of bioactive compounds from agarwood leaves. In: IOP Conference Series: Materials Science and Engineering. Vol. 162. London, United Kingdom: IOP Publishing; 2016. p. 012028.

18. Pereira DT, Tarone AG, Cazarin CB, Barbero GF, Martínez J. Pressurized liquid extraction of bioactive compounds from grape marc. J Food Eng 2019;240:105-13.

19. Azmir J, Zaidul IS, Rahman MM, Sharif KM, Mohamed A, Sahena F, et al. Techniques for extraction of bioactive compounds from plant materials: A review. J Food Eng 2013;117:426-36.

20. Booker A, Johnston D, Heinrich M. Value chains of herbal medicines-research needs and key challenges in the context of ethnopharmacology. J Ethnopharmacol 2012;140:624-33.

21. Swargiary G, Rawal M, Singh M, Mani S. Molecular approaches to screen bioactive compounds from medicinal plants. In: Plant-derived Bioactives. Singapore: Springer; 2020. p. 1-32.

22. Wang L, Weller CL. Recent advances in extraction of nutraceuticals from plants. Trends Food Sci Technol 2006;17:300-12.

23. Das AK, Adsare SR, Das M, Kulthe PS. Advanced techniques in extraction of phenolics from cereals, pulses, fruits, and vegetables. In: Plant Secondary Metabolites. Vol. 2. United States: Apple Academic Press; 2017. p. 53-102.

24. Alkasir RS, Ornatska M, Andreescu S. Colorimetric paper bioassay for the detection of phenolic compounds. Anal Chem 2012;84:9729-37.

25. Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha LY. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr J Tradit Complement Altern Med 2011;8:1-10.

26. Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, et al. Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nat Commun 2017;8:1-2.

27. Shelef O, Weisberg PJ, Provenza FD. The value of native plants and local production in an era of global agriculture. Front Plant Sci 2017;8:2069.

28. Granato D, Nunes DS, Barba FJ. An integrated strategy between food chemistry, biology, nutrition, pharmacology, and statistics in the development of functional foods: A proposal. Trends Food Sci Technol 2017;62:13-22.

29. Damjanovi?-Vratnica B. Herbal extracts-possibility of preventing food-borne infection. In: Significance, Prevention and Control of Food Related Diseases. India: IntechOpen; 2016. p. 275.

30. Bartwal A, Mall R, Lohani P, Guru SK, Arora S. Role of secondary metabolites and brassinosteroids in plant defense against environmental stresses. J Plant Growth Reg 2013;32:216-32.

31. Ansari FA, Gupta SK, Shriwastav A, Guldhe A, Rawat I, Bux F. Evaluation of various solvent systems for lipid extraction from wet microalgal biomass and its effects on primary metabolites of lipid-extracted biomass. Environ Sci Poll Res 2017;24:15299-307.

32. Wink M. Modes of action of herbal medicines and plant secondary metabolites. Medicines 2015;2:251-86.

33. Nilsson M, Zamparutti T, Petersen JE, Nykvist B, Rudberg P, McGuinn J. Understanding policy coherence: Analytical framework and examples of sectorenvironment policy interactions in the EU. Environ Pol Gov 2012;22:395-423.

34. Sansinenea E, Ortiz A. Secondary metabolites of soil Bacillus spp. Biotechnol Lett 2011;33:1523-38.

35. Rohlfs M, Churchill AC. Fungal secondary metabolites as modulators of interactions with insects and other arthropods. Fungal Gen Biol 2011;48:23-34.

36. Guaadaoui A, Benaicha S, Elmajdoub N, Bellaoui M, Hamal A. What is a bioactive compound? A combined definition for a preliminary consensus. Int J Nutr Food Sci 2014;3:174-9.

37. Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 2016;7:27.

38. Sosa-Hernández JE, Escobedo-Avellaneda Z, Iqbal H, Welti-Changes J. State-of-the-art extraction methodologies for bioactive compounds from algal biome to meet bio-economy challenges and opportunities. Molecules 2018;23:2953.

39. Yang X, Van Der Donk WA. Ribosomally synthesized and post?translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis. Chem Eur J 2013;19:7662-77.

40. Kemp IK. Identification and Preliminary Characterization of 2, 5-Diphenyloxazole Biosynthetic Pathway in Streptomyces Polyantibioticus SPRT. Ph.D. Diss. South Africa: University of Cape Town; 2015.

41. Muhsinah AB. Phytochemical Investigations of a Native North American Species, Acer Saccharinum and an Endemic Saudi Arabian Species, Euphorbia Saudiarabica. Ph.D. Diss. Rhode Island: University of Rhode Island; 2018.

42. Panja P. Green extraction methods of food polyphenols from vegetable materials. Curr Opin Food Sci 2018;23:173-82.

43. Donno D, Boggia R, Zunin P, Cerutti AK, Guido M, Mellano MG, et al. Phytochemical fingerprint and chemometrics for natural food preparation pattern recognition: An innovative technique in food supplement quality control. J Food Sci Technol 2016;53:1071-83.

44. Luki? I, Budi?-Leto I, Bubola M, Damijani? K, Staver M. Pre-fermentative cold maceration, saignée, and various thermal treatments as options for modulating volatile aroma and phenol profiles of red wine. Food Chem 2017;224:251-61.

45. Ayestarán B, Martínez-Lapuente L, Guadalupe Z, Canals C, Adell E, Vilanova M. Effect of the winemaking process on the volatile composition and aromatic profile of tempranillo Blanco wines. Food Chem 2019;276:187-94.

46. Mojzer EB, Hrn?i? MK, Škerget M, Knez Ž, Bren U. Polyphenols: Extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules 2016;21:901.

47. Mercer P, Armenta RE. Developments in oil extraction from microalgae. Eur J Lipid Sci Technol 2011;113:539-47.

48. Liu J, Li M, Luo X, Chen L, Huang L. Effect of hot-water extraction (HWE) severity on bleached pulp based biorefinery performance of eucalyptus during the HWE-Kraft-ECF bleaching process. Bioresour Technol 2015;181:183-90.

49. Saifuddin N, Saltanat A, Refal H. Enhancing the removal of phenolic compounds from palm oil mill effluent by enzymatic pre-treatment and microwave-assisted extraction. Chem Sci Trans 2014;3:1083-93.

50. Sasidharan S, Jothy SL, Vijayarathna S, Kavitha N, Oon CE, Chen Y, et al. Conventional and non-conventional approach towards the extraction of bioorganic phase. In: Bioorganic Phase in Natural Food. Cham: Springer; 2018. p. 41-57.

51. Solakoglu Ö, Götz W, Heydecke G, Schwarzenbach H. Histological and immunohistochemical comparison of two different allogeneic bone grafting materials for alveolar ridge reconstruction: A prospective randomized trial in humans. Clin Implant Dent Relat Res 2019;21:1002-16.

52. Sell A, Fadaei H, Kim M, Sinton D. Measurement of CO2 diffusivity for carbon sequestration: A microfluidic approach for reservoir-specific analysis. Environ Sci Technol 2013;47:71-8.

53. Muhamad II, Hassan ND, Mamat SN, Nawi NM, Rashid WA, Tan NA. Extraction technologies and solvents of phytocompounds from plant materials: Physicochemical characterization and identification of ingredients and bioactive compounds from plant extract using various instrumentations. In: Ingredients Extraction by Physicochemical Methods in Food. United States: Academic Press; 2017. p. 523-60.

54. Naviglio D, Scarano P, Ciaravolo M, Gallo M. Rapid solid-liquid dynamic extraction (RSLDE): A powerful and greener alternative to the latest solid-liquid extraction techniques. Foods 2019;8:245.

55. ?uji? N, Šavikin K, Jankovi? T, Pljevljakuši? D, Zduni? G, Ibri? S. Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. Food Chem 2016;194:135-42.

56. Naima R, Oumam M, Hannache H, Sesbou A, Charrier B, Pizzi A, et al. Comparison of the impact of different extraction methods on polyphenols yields and tannins extracted from Moroccan Acacia mollissima barks. Ind Crops Prod 2015;70:245-52.

57. Coelho EM, de Souza ME, Corrêa LC, Viana AC, de Azevêdo LC, dos Santos Lima M. Bioactive compounds and antioxidant activity of mango peel liqueurs (Mangifera indica L.) produced by different methods of maceration. Antioxidants 2019;8:102.

58. Albuquerque BR, Prieto MA, Vázquez JA, Barreiro MF, Barros L, Ferreira IC. Recovery of bioactive compounds from Arbutus unedo L. fruits: Comparative optimization study of maceration/microwave/ultrasound extraction techniques. Food Res Int 2018;109:455-71.

59. Rasul MG. Extraction, isolation and characterization of natural products from medicinal plants. Int J Basic Sci Appl Comput 2018;2:1-6.

60. Santos A, Barros L, Calhelha RC, Dueñas M, Carvalho AM, Santos-Buelga C, et al. Leaves and decoction of Juglans regia L.: Different performances regarding bioactive compounds and in vitro antioxidant and antitumor effects. Ind Crops Prod 2013;51:430-6.

61. Martins N, Barros L, Santos-Buelga C, Henriques M, Silva S, Ferreira IC. Decoction, infusion and hydroalcoholic extract of Origanum vulgare L.: Different performances regarding bioactivity and phenolic compounds. Food Chem 2014;158:73-80.

62. Eman AE, Shoaib AM. Re-refining of used lube oil, II-by solvent/clay and acid/ clay-percolation processes. ARPN J Sci Technol 2012;2:1034-41.

63. Hashemi Z, Ebrahimzadeh MA. Evaluation of three methods for the extraction of antioxidants from Vicia faba L. Bean and hulls. Latin Am Appl Res 2014;44:203-8.

64. dos Santos MA, Alicieo TV, Pereira CM, Ramis-Ramos G, Mendonça CR. Profile of bioactive compounds in avocado pulp oil: Influence of the drying processes and extraction methods. J Am Oil Chem Soc 2014;91:19-27.

65. Mohamed HB, Duba KS, Fiori L, Abdelgawed H, Tlili I, Tounekti T, et al. Bioactive compounds and antioxidant activities of different grape (Vitis vinifera L.) seed oils extracted by supercritical CO2 and organic solvent. LWT 2016;74:557-62.

66. Bae H, Jayaprakasha GK, Jifon J, Patil BS. Variation of antioxidant activity and the levels of bioactive compounds in lipophilic and hydrophilic extracts from hot pepper (Capsicum spp.) cultivars. Food Chem 2012;134:1912-8.

67. Alara OR, Abdurahman NH, Ukaegbu CI. Soxhlet extraction of phenolic compounds from Vernonia cinerea leaves and its antioxidant activity. J Appl Res Med Arom Plants 2018;11:12-7.

68. Shahidi F, Yeo J. Should the in vitro colorimetric assays in antioxidant and lipid oxidation evaluation be abandoned?: A critical review focusing on bioactive molecule screening assays in in vitro and in vivo models. J Food Bio 2020;9:9215.

69. Barbosa AM, Santos KS, Borges GR, Muniz AV, Mendonça FM, Pinheiro MS, et al. Separation of antibacterial biocompounds from Hancornia speciosa leaves by a sequential process of pressurized liquid extraction. Sep Purificat Technol 2019;222:390-5.

70. Viganó J, Brumer IZ, de Campos Braga PA, da Silva JK, Júnior MR, Reyes FG, et al. Pressurized liquids extraction as an alternative process to readily obtain bioactive compounds from passion fruit rinds. Food Bioprod Proc 2016;100:382-90.

71. Soumya SB, Sawant AA, Khandetod YP, Mohod AG, Dhekale JS. Extraction methods used for extraction of anthocyanin: A review. Pharma Innov J 2019;8:280-5.

72. Gallo M, Formato A, Ianniello D, Andolfi A, Conte E, Ciaravolo M, et al. Supercritical fluid extraction of pyrethrins from pyrethrum flowers (Chrysanthemum cinerariifolium) compared to traditional maceration and cyclic pressurization extraction. J Super Fluids 2017;119:104-12. 73. Espinosa-Pardo FA, Martinez J, Martinez-Correa HA. Extraction of bioactive compounds from peach palm pulp (Bactris gasipaes) using supercritical CO2. J Super Fluids 2014;93:2-6. 74. Kumar K, Srivastav S, Sharanagat VS. Ultrasound-assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: A review. Ultrason Sonochem 2020;70:105325.

75. Goltz C, Ávila S, Barbieri JB, Igarashi-Mafra L, Mafra MR. Ultrasound-assisted extraction of phenolic compounds from Macela (Achyrolcine satureioides) extracts. Ind Crops Prod 2018;115:227-34.

76. Hoppe A. Examination of Egg White Proteins and Effects of High Pressure on Select Physical and Functional Properties. Lincoln: University of Nebraska; 2010.

77. Alexandre AM, Matias A, Duarte CM, Bronze MR. High-pressure CO2 assisted extraction as a tool to increase phenolic content of strawberry-tree (Arbutus unedo) extracts. J Utilizat 2018;27:73-80.

78. de Aguiar AC, da Fonseca Machado AP, Angolini CF, de Morais DR, Baseggio AM, Eberlin MN, et al. Sequential high-pressure extraction to obtain capsinoids and phenolic compounds from biquinho pepper (Capsicum chinense). J Super Fluids 2019;150:112-21.

79. Mohammad Azmin SN, Abdul Manan Z, Wan Alwi SR, Chua LS, Mustaffa AA, Yunus NA. Herbal processing and extraction technologies. Separat Purificat Rev 2016;45:305-20.

80. Hossain MB, Barry-Ryan C, Martin-Diana AB, Brunton NP. Optimisation of accelerated solvent extraction of antioxidant compounds from rosemary (Rosmarinus officinalis L.), marjoram (Origanum majorana L.) and oregano (Origanum vulgare L.) using response surface methodology. Food Chem 2011;126:339-46.

81. Rodríguez-Solana R, Salgado JM, Domínguez JM, Cortés-Diéguez S. Characterization of fennel extracts and quantification of estragole: Optimization and comparison of accelerated solvent extraction and Soxhlet techniques. Ind Crops and Prod 2014;52:528-36.

82. Boulila A, Hassen I, Haouari L, Mejri F, Amor IB, Casabianca H, et al. Enzyme-assisted extraction of bioactive compounds from bay leaves (Laurus nobilis L.). Ind Crops Prod 2015;74:485-93.

83. Vásquez V, Martínez R, Bernal C. Enzyme-assisted extraction of proteins from the seaweeds Macrocystis pyrifera and Chondracanthus chamissoi: Characterization of the extracts and their bioactive potential. JAppl Phycol 2019;31:1999-2010