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PHARMASPIRE - Volume 13, Issue 3, July - September, 2021

Pages: 117-121

Date of Publication: 07-Jun-2022

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Simultaneous estimation of simvastatin and fenofibrate from their combined dosage form by ultraviolet–visible spectroscopy using simultaneous equation method

Author: Geeta Rajput, Saranjit Singh, Balak Das Kurmi

Category: Pharmaceutics


Objective: This research paper describes a simple, precise, and accurate UV-Vis Spectrophotometric method was developed and validated for simultaneous estimation of simvastatin (SIM) and fenofibrate (FEN) from their combination dosage form.

Method: This method includes forming and solving a simultaneous equation using 238 nm and 287 nm as two analytical wavelengths (λmax of the drugs) of detection. Both the drugs followed Beer-Lambert’s law over the concentration range 0.60-3.60 μg/mL for simvastatin and 4.35-26.10 μg/mL for fenofibrate, respectively.

Results: Validation of the new developed method was done by linearity, precision, accuracy, limit of detection, limit of quantitation and robustness as per ICH guidelines and the results of the analysis were validated statistically.

Conclusion: The available information from the research will be very informative towards the multi-component analysis of these drugs and will open new paradigms in the upcoming research in the field of analysis.

Keywords: Fenofibrate, simultaneous equation method, simvastatin, ultraviolet– visible spectroscopy


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