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PHARMASPIRE - Volume 13, Issue 4 , October - December, 2021

Pages: 182-193

Date of Publication: 02-Jun-2022

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Design, synthesis and evaluation of some newly synthesized Pyranoquinolinone derivatives as potential antimicrobial agents

Author: Jasreen Uppal, Preet Mohinder Singh Bedi, Amarjit Kaur, Kanaya Lal Dhar

Category: Pharmaceutics


A mild and efficient method for the synthesis of (JCMQ-1-24) through a twocomponent reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone (JC-1) and intermediate arylidenes (JCM-1-24) catalyzed by piperidine is described. This new procedure has the advantages of mild reaction condition, high yields, and metal-free catalyst. A library of 22 pyranoquinolinone derivatives, with substituents at positions 2, 3, 4, and 5 were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depends on the substituents attached to the pyran ring.

Keywords: Aromatase, 4-Hydroxy-1-methyl-2(1H)-quinolinone, knoevenagel condensation, pyranoquinolinones, antimicrobial activity


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