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PHARMASPIRE - Volume 13, Issue 4 , October - December, 2021

Pages: 182-193
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Design, synthesis, and characterization of new thiazolidinedione derivatives as potent α-glucosidase inhibitors

Author: Sobhi Gaba, Gurpreet Singh, Vikramdeep Monga

Category: Pharmaceutics


In an effort to find new antidiabetic agents, we carried out the design and synthesis of new thiazolidinedione derivatives and evaluated them as α-glucosidase inhibitors. All the synthesized derivatives were evaluated for α-glucosidase inhibitory activity. All the derivatives showed good inhibitory potential against α-glucosidase with IC50 values ranging between 35.74 ± 0.134 and 12.29 ± 1.86 μg/mL. Among all the synthesized derivatives, 12d emerged to be the most potential inhibitor of α-glucosidase bearing IC50 value of 12.29 ± 1.86 μg/mL. Owing to the results, it can be concluded that the lead identified in the present study can be further explored for the design of potent α-glucosidase inhibitors as antidiabetic agents.

Keywords: Thiazolidinedione, ?-glucosidase inhibitors, antidiabetic agents, synthesis, in vitro studies


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