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PHARMASPIRE - Volume 13, Issue 4 , October - December, 2021

Pages: 151-156
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Semaglutide: An expedition on last approved glucagon-like peptide-1 analog of past decade

Author: nkit Kumar Rai, Kankan Roy, Rajib Das, SantKumar Verma

Category: Pharmaceutics


Semaglutide (Ozempic once in a week sub-cutaneous injection; Rybelsus: Oral tablet) is a glucagon-like peptide 1 receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). It was the last United States Food and Drug Administration (FDA) approved drug, developed by Novo Nordisk, of the past decade for the treatment of type 2 diabetes. The current expedition on semaglutide will update the clinician and researchers about the different aspects of the newer drug including FDA approval and market authorization, description of structural class, mechanism, pharmacokinetics, pre-clinical studies, clinical studies, dosages, adverse effects, and interactions.

Keywords: Glucagon-like peptide 1, oral anti-diabetic, semaglutide, type 2 diabetes mellitus


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