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Original Article
Year : 2018   |  Volume : 10  |  Issue : 3  |  Page : 121-131

Neuroprotective potential of Mangosteen in 3-nitropropionic acid-induced Huntington’s disease like behavioral and biochemical alterations in rats

Huntington’s disease (HD) is an autosomal dominantly inherited progressive neurodegenerative disorder, characterized by progressively worsening chorea, psychiatric disturbances, cognitive impairment, and weight loss. Gamma-aminobutyric acid-ergic neurons, medium spiny striatal neurons, and cortical neurons are involved in the progression of the neurodegeneration. Impaired energy metabolism, excitotoxicity, microglial activation, and production of pro-inflammatory cytokines leading to neuronal death, by both necrosis and apoptosis, are the major hallmarks of HD. Mangosteen (MGST) contains xanthones which are reported to have antioxidant properties. 3-nitropropionic acid (3-NP) is used to induce HD in animals. MGST (50, 100, and 150 mg/kg orally) was used for 14 days as a treatment for neurotoxicity. Further, MGST treatment significantly improved mitochondrial complex enzyme activity, attenuated inflammatory, and oxidative damage to the brain. In the current study, for the first time, we have tried to further explore the role of MGST as a pharmacological tool in 3-NP-induced neurotoxicity.
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