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[An Official Publication of ISF College of Pharmacy, Moga]


 

Original Article
Year : 2018   |  Volume : 10  |  Issue : 2  |  Page : 87-94

Histoarchitectural and biochemical investigation of cardiac myocytes in rat model of isoproterenol-induced myocardial infarction with the exploration of boswellic acid

Myocardial infarction is a condition in which loss of myocytes takes place due to prolonged ischemic condition and adrenergic overactivation. Isoproterenol, a synthetic catecholamine and a non-selective β-adrenergic agonist, is often employed in high dose to induce experimental myocardial infarction in order to study cardioprotective anti-infarct effects of pharmacological interventions. Induction of high oxidative stress in the heart is one of key events that could contribute to isoproterenol-induced experimental myocardial infarction. Boswellic acids have potent anti-inflammatory properties, and it has been shown to be beneficial against various inflammatory disorders. In addition to its anti-inflammatory action, boswellic acids have a potent antioxidant potential. However, the protective effect of boswellic acids (250 mg/kg, p.o.) on experimentally induced myocardial infarction has not been investigated. Therefore, the present study has been designed to investigate the effect of boswellic acids against isoproterenol-induced (85 mg/kg, s.c.) myocardial infarction in rats. The present study provides experimental evidence that boswellic acids augmented the myocardial antioxidant enzyme level, preserved histoarchitecture, and improved cardiac performance by changing marker level following isoproterenol administration.
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