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[An Official Publication of ISF College of Pharmacy, Moga]


Original Article
Year : 2018   |  Volume : 10  |  Issue : 2  |  Page : 64-67

Method development and validation of mefenamic acid, dicyclomine hydrochloride, and pamabrom of marketed formulation by ultraviolet

The method has been developed and validated using the spectrophotometric technique for the simultaneous estimation of mefenamic acid (MEF), dicyclomine hydrochloride (DCL), and pamabrom (PABr) in bulk powder and in pharmaceutical formulations with a high degree of specificity, selectivity, and assurances. The first Vierdot’s method was performed and absorption maxima of MEF, DCL, and PABr at 285, 214.6, and 279 nm, respectively. Calibration graphs were established in the range of 2–10 μg/mL for MEF and PABr and 200–1000 μg/mL for DCL. Dilution was prepared in 0.1 N sodium hydroxide.
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