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[An Official Publication of ISF College of Pharmacy, Moga]


 

Original Article
Year : 2019   |  Volume : 11  |  Issue : 3  |  Page : 88-92

Synthesis, structural identification, and biological evaluation of naphthalene-based pyrimidine

Increasing drug resistance in bacteria and cancer has alarmed the rings to develop newer, safer, and effective treatments against them. In a quest to identify new leads, we synthesized some naphthalene-based pyrimidines and evaluated their antibacterial and cytotoxic potential. The molecules were synthesized through the condensation of naphthalene-based chalcone with guanidine hydrochloride in methanol under reflux conditions. The antibacterial evaluation led to the identification of compound 5b as the most potent molecule of the series. Compound 5c was found to be the most potent against colo-205, while 5a displayed the highest activity against A-549.
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